Inspired by the fascinating working process of living systems, materials that can respond to external stimuli (mechanical, chemical, optical changes in environmental conditions, etc.) are of enormous interest owing to their applications in a wide range of fields including microfluidic devices, drug delivery, tissue engineering, sensors and actuators. This review, while being non-exhaustive in l...

Abstract Polymer science has applications in biomedical engineering, prosthetics, surgical implants, and prospective pharmaceutical excipients for drug delivery. “Intelligent or Smart Polymers” are created targeting either by derivatization of natural polymers controlled radical polymerization electrolytes. Their mode action is governed the environmental stimuli viz. temperature, pH, ionic conc...

Temperature- and pH-responsive dispersions of carbon nanotubes in water have been obtained by using di- and tri-block copolypeptides, in which the temperature responsive behaviour is provided by a poly(N-isopropylacrylamide) block, while the pH responsiveness is provided by two different polypeptides with an ampholytic behaviour, poly(L-glutamic acid) and poly(L-lysine). The molecular architect...

Surfactants are among the most versatile and widely used excipients in pharmaceuticals. This versatility, together with their pH-responsive membrane-disruptive activity and low toxicity, could also enable their potential application in drug delivery systems. Five anionic lysine-based surfactants which differ in the nature of their counterion were studied. Their capacity to disrupt the cell memb...

pH-sensitive drug targeting using nanoparticles for cancer chemotherapy have been spotlighted in recent decades. Graft copolymer composed of poly (L-histidine) (PHS) and dextran (DexPHS) was synthesized and pH-sensitive nanoparticles were fabricated for pH-responsive drug delivery of doxorubicin (DOX). Nanoparticles of DexPHS showed pH-sensitive changes in particle sizes and drug release behavi...

Ionically crosslinked hydrogels based on TEMPO nanocelullose and alginate were prepared to develop a generalized pH value, temperature biopolymer concentration dependent mathematical model. The distinctive attention was in the demonstration of hydrogen bonds effects model, prevailing especially field low crosslink densities nanocellulose hydrogel acid medium. Accordingly, subjected research as ...

As a pH-sensitive nanomaterial, Eudragit S100 has good colon targeting. However, little research been carried out on its mesoscopic scale. In this paper, the self-assembly behavior of Pulsatilla saponins D (PSD) and S100, as well loading release mechanism PSD, was investigated via computer simulations. The effects characteristics PSD in dry powder state drug-carrier ratio were explored by coars...