Objective: The present study is aimed to investigate in vitro thrombolytic activity of three Bangladeshi medicinal plants Averrhoa bilimbi (Oxalidiaceae), Clerodendrum viscosum (Verbanaceae) and Drynaria quercifolia (Polypodiaceae). Materials and methods: Each the plant was extracted with methanol at room temperature and the concentrated methanolic extracts (MEF) were fractionated by the modifi...

ON October 16, 1968, a nationwide cooperative study was officially begun to assess the therapeutic efficacy of urokinase in acute pulmonary thromboembolism. The beginning of the "Urokinase-Pulmonary Em-bolism Trial" was the culmination of the efforts of many individuals* during the course of several years. The fact that the study is now in progress is in large part a result of extensive coopera...

In recent decades, the management of patients with suspected acute myocardial infarction (MI) has progressed substantially through the testing (and acceptance or rejection) of a number of different hypotheses. In the 1960s, recognition of the risks of early ventricular fibrillation led to the establishment of coronary care units, emphasis on early hospitalization of patients, and often, the use...

BACKGROUND The benefit of intravenous thrombolytic therapy in elderly patients with myocardial infarction is uncertain. There are no randomized trials of thrombolytic efficacy or observational studies of clinical effectiveness that focus specifically on the elderly. METHODS AND RESULTS To determine whether thrombolytic therapy for elderly patients is associated with a survival advantage in a ...

Do Not Substitute: IV Thrombolytic Selection Errors in Acute Stroke To the Editor: Activase (alteplase), commonly referred to as tPA, is a tissue-type plasminogen activator approved for treatment of ischemic stroke when given within 3 hours of symptom onset. Of the 6 thrombolytic drugs licensed for any use in the United States, Retaplase (reteplase), and TNKase (tenecteplase) share this mechani...

Background. Streptokinase is a routinely used thrombolytic agent that is immunogenic and relatively inefficient toward platelet-rich thrombus, whereas staphylokinase is a poorly studied fibrinolytic agent. Here, the comparative immunogenicity and thrombolytic properties toward arterial platelet-rich thrombus and venous whole blood clots of streptokinase and recombinant staphylokinase were studi...