A 42-year-old male presented with a one-week history of palpitations and sweating episodes. The only significant history was of longstanding idiopathic dilated cardiomyopathy. Initial ECG demonstrated a sinus tachycardia. Thyroid function testing, undertaken as part of the diagnostic workup, revealed an un-measureable thyroid-stimulating hormone (TSH) and free thyroxine (T4). Upon questioning t...

Introduction:Differentiated thyroid carcinoma (DTC) follow-up after thyroidectomy and radioiodine-ablation is performed mainly by thyroglobulin (Tg), diagnostic iodine-131 whole body scan (DxWBS) and sonography. Some patients with undetectable Tg have thyroid-bed uptake after ablation in whom decision making regarding the need for retreatment is still controversial. Me...

Measurement of the rate of accumulation of radioiodine by the thyroid gland is of considerable clinical value, since in most instances an avid uptake of radioiodine may be correctly assumed to be due to a high rate of uptake of stable iodide by the thyroid. This measurement, expressed as a percentage of the administered radioiodine dose accumulated per unit time by the thyroid, does not give a ...

Purpose To evaluate the possible roles of miR-34a expression in thyroid lesions, to unravel the correlation between fluorodeoxyglucose (FDG) uptake and miR-34a expression and moreover, to discover the underlying mechanisms by which miR-34a regulates FDG avidity. Methods We retrospectively reviewed 75 patients with pathology-confirmed thyroid diseases who underwent 18F-FDG positron emission to...

INTRODUCTION The aim of the study was to compare the success rate of an uptake-related ablation protocol in which the dose depends on an I-131 24-h neck uptake measurement and a fixed-dose ablation protocol in which the dose depends on tumour stage. METHODS All differentiated thyroid carcinoma patients with M0 disease who had undergone (near-) total thyroidectomy followed by I-131 ablation we...

Introduction Increasing numbers of patients are receiving treatment with the tranquillizing drugs, and patients referred to hospital with suspected thyrotoxicosis are often taking such drugs. It is important to know what effects these drugs have on tests of thyroid function if diagnostic confusion is to be avoided. Diazepam is a commonly prescribed centrallyacting tranquillizer. Published work ...

Introduction Increasing numbers of patients are receiving treatment with the tranquillizing drugs, and patients referred to hospital with suspected thyrotoxicosis are often taking such drugs. It is important to know what effects these drugs have on tests of thyroid function if diagnostic confusion is to be avoided. Diazepam is a commonly prescribed centrallyacting tranquillizer. Published work ...

Introduction. Although whole body scan (WBS) with I-131 is a highly sensitive tool for detecting normal thyroid tissue and metastasis of differentiated thyroid cancer (DTC), it is not specific. Additional information, provided by single photon emission computed tomography combined with X-ray computed tomography (SPECT/CT) and by the serum thyroglobulin level, is extremely useful for the interpr...

Liver uptake of thyroxine (T4) is mediated by transporters and is rate limiting for hepatic 3,3',5-triiodothyronine (T3) production. We investigated whether hepatic mRNA for T4 transporters is regulated by thyroid state using Xenopus laevis oocytes as an expression system. Because X. laevis oocytes show high endogenous uptake of T4, T4 sulfamate (T4NS) was used as an alternative ligand for the ...