Objective: Invasive surgical interventions creating acute stress may give rise to immunological and hormonal disturbances in patients undergoing surgery. Previous studies reported elevations in serum prostate-specific antigen (PSA) level following coronary bypass and myocardial infarction. The current study aims to investigate the effect of surgical stress on serum PSA level. Methods: Thirty-th...

Purpose: To investigate in silico the drug-like properties of alkaloids (arecoline, arecaidine, guvacine, guvacoline, isoguvacine, arecolidine and homoarecoline) obtained from the fruits of Areca catechu L (areca nut). Methods: All chemical structures were re-drawn using Chemdraw Ultra 11.0. Furthermore, software including Bio-Loom for Windows version 1.5, Molinspiration Property Calculator and...

BACKGROUND To date, no published nomogram for prostate cancer (PCa) risk prediction has considered the between-method differences associated with estimating concentrations of prostate-specific antigen (PSA). METHODS Total PSA (tPSA) and free PSA were measured in 780 biopsy-referred men with 5 different assays. These data, together with other clinical parameters, were applied to 5 published no...

Benign prostatic hyperplasia (BPH) is an enlargement of the prostate. The study aimed at validating the use of freeze-dried Croton membranaceus ethanolic root extract for BPH management. Thirty-three patients were observed before and after 3-month administration of 20 mg t.i.d orally. The International Prostate Symptom Score (IPSS), and the International Index of Erectile Function (IIEF) questi...

PURPOSE This study was conducted to evaluate the incidence of prostate cancer (PCa) in Iranian male patients with increased prostate-specific antigen (PSA), and normal or abnormal digital rectal examination (DRE) that underwent prostate biopsy. MATERIALS AND METHODS From March 2006 to April 2009, a total of 346 consecutive males suspected of having PCa due to increased PSA levels underwent tr...

PURPOSE Previous studies suggest that vascular endothelial growth factor (VEGF) circulating levels might improve identification of patients with prostate cancer but results are conflicting. Our aim was to compare serum VEGF levels across different prostate pathologies (including benign prostatic hyperplasia, prostatitis, high grade prostate intraepithelial neoplasia and prostate cancer) in pati...

多峰性の連続最適化問題にシミュレーテッドアニーリング (SA)を適用する場合,著者らがすでに 提案している最適な受理確率を目標とする適応的近傍を持つ SA(SA/AAN)が有効である.本論文 では,並列計算機を用いて組み合わせ最適化問題を解く場合に有効な並列アルゴリズムの 1つである 温度並列シミュレーテッドアニーリング (TPSA)に SA/AAN を組み込んだ手法を提案する.提案 手法は各プロセス (プロセッサ)が担当する各温度において,適応的な近傍拡大率を持つ近傍を用い て探索するため,関数のランドスケープに適応した探索が行うことが可能である.一方,TPSAは温 度スケジュールが不要であるという特徴がある.そのため本論文で提案する手法は,温度,近傍とも に関数のランドスケープに合わせ自律的な調節を行うことができるという優れた特徴を持つことがわ かった.3 つの代表的なテスト関数...

OBJECTIVE To identify factors that might explain why a prostate with a Gleason score (GS) <7 in the biopsy specimen can turn out to have a GS ≥7 in the surgical specimen. MATERIAL AND METHODS We compared the GS of biopsy specimens with the GS of surgical specimens in 185 patients who underwent surgery for prostate cancer. We calculated the sensitivity, specificity, and predictive values for t...