In multiple myeloma (MM), malignant plasma cells reside in the bone marrow, where they accumulate in close contact with stromal cells. The mechanisms responsible for the chemotaxis of malignant plasma cells are still poorly understood. Thus, we investigated the mechanisms involved in the chemotaxis of MDN and XG2 MM cell lines. Both cell lines strongly expressed CCR9, CXCR3 and CXCR4 chemokine ...

We show that the Gentzen-style classical logic LKT, as presented in Danos et al.(1993), can be considered as the classical call-by-name (CBN) calculus. First, we present a new term calculus for LKT which faithfully simulates cut-elimination procedure, namely tq-protocol. Then, we give a translation of Parigot's -calculus. This translation can be seen as the classical extension to the Plotkin's ...

parkinson disease (pd) is the most common movement disorder with progressive degeneration of midbrain dopaminergic neurons for which current treatments afford symptomatic relief with no-prevention of disease progression. due to the neuroprotective property of the nigella sativa bioactive compound thymoquinone (tq), this study was undertaken to evaluate whether tq could improve behavioral and ce...

Cancer is one of the main causes of mortality in the world which appears by the effect of enviromental physico-chemical mutagen and carcinogen agents. The identification of new cytotoxic drugs with low side effects on immune system has developed as important area in new studies of immunopharmacology. Thymoquinone (TQ), derived from the medicinal spice Nigella sativa (also called black cumin) ex...

BACKGROUND One of the major causes of clinical trial termination is the liver toxicity induced by chemotherapeutic agents. Treatment with anticancer drugs like CB 1954 (5-(Aziridin-1-yl)-2,4-dinitrobenzamide) is associated with significant hepatotoxicity. Thymoquinone (TQ), extracted from Nigella sativa, is reported to possess anticancer and hepatoprotective effects. The aims of the present stu...

Working Tomorrow / Business Unit Technical Software Engineering Faculty of Electrical Engineering, Mathematics and Computer Science CE-MS-2006-04 Currently emerging flat plasma and LCD television sets, provide a higher resolution and better color quality than the conventional CRT TVs. To fully utilize the capabilities of these displays, Standard Definition video material need to be enhanced in ...

INTRODUCTION Triple quantum (TQ) sodium imaging is an effective means decreasing the contribution from the intracellular and fluid spaces to the sodium (Na) signal. This increased intra-cellular contrast is highly desirable for the study of pathologies such as cancer and stroke. The sodium TQ signal is, however, much weaker than the single quantum (SQ, or total tissue) signal (~1/10). It is, th...

Parkinson disease (PD) is the most common movement disorder with progressive degeneration of midbrain dopaminergic neurons for which current treatments afford symptomatic relief with no-prevention of disease progression. Due to the neuroprotective property of the Nigella sativa bioactive compound thymoquinone (TQ), this study was undertaken to evaluate whether TQ could improve behavioral and ce...

black seed (nigella sativa) is considered as a biological response modifier. thymoquinone (tq) is the bioactive and the most abundant constituent of the volatile oil of this seed which has been shown to possess anti-inflammatory, antioxidant and anti-neoplastic effects. in this study, the effect of tq on hepg2 cell line was investigated in an attempt to identify its potential mechanism of actio...