Mexico's need for uniform information about drug abuse led to creation of an information collection system in 1986. This system, known as the System for Registry of Information on Drugs (SRID), currently covers the Mexico City metropolitan area. Plans call for it to be expanded in two phases--so as to provide coverage first of the states near the U.S. border and those with substantial tourism, ...

From the late 1960s to the early 1990s America has experienced a truly dramatic epidemic of illicit drug use, among its adolescents and young adults in particular. It has been an epidemic that to some degree has diffused to practically all other comers of the globe, although what piecemeal epidemiological data are available suggest that in no other region did the epidemic penetrate the youthful...

OBJECTIVE To describe the prevalence of illicit drug consumption among adolescents and the motives that led these adolescents to try them. METHODS Cross-sectional study with 2,499 adolescents aged 17 years, based on a cohort called EPITeen, which was started in 2003/2004 with adolescents born in 1990 who studied in public and private schools of the city of Porto, Portugal. A new assessment wa...

Tapentadol is a novel oral analgesic with a dual mode of action as an agonist of the µ-opioid receptor (MOR), and as a norepinephrine reuptake inhibitor (NRI) all in a single molecule. Immediate release (IR) tapentadol shows its analgesic effect quickly, at around 30 minutes. Its MOR agonistic action produces acute nociceptive pain relief; its role as an NRI brings about chronic neuropathic pai...

Haloperidol (i.e. HPD) and hydroxyzine (i.e. HXY), two effective and important tranquilizers with low redox activity, were found to generate an irreversible anodic peak at about +0.86 V (vs. SCE) or two anodic peaks at about +0.83 and +0.91 V in 0.05 M NaH₂PO₄-Na₂HPO₄ (pH=7.0) buffer solution with a multi-walled carbon nanotubes-modified glassy carbon electrode (i.e. MWNTs/GC), respectively. Th...

OBJECTIVE Although widely used in the general population, sleeping pills and minor tranquilizers, also known as antianxiety agents, have been associated with undesirable outcomes. Reports about the association of these drugs with an elevated mortality rate are inconsistent and controversial. This study was designed to assess the mortality hazard associated with anxiolytic and hypnotic drug use ...

Since the advent of use of phenothiazine derivatives as "tranquilizing" drugs, physicians have become aware of the occurrence of severe contact dermatitis in response to administration or handling of certain members of this chemical group (1—3). In addition, clinical observations (4) of the course of jaundice in patients taking oral doses of tranquilizers of this group strongly suggest that oth...

In an earlier article in this Journal, we reported analyses that differentiated among period, age, and cohort effects on substance use among American youth 18 to 24 years old, from the high school classes of 1976 to 1982 during the period of 1976 to 1982. The present analyses extend the classes and years to 1986, and the age range to 18-28. A cohort-sequential design is employed, based on annua...