ᅟ: Accurate and quantitative dosimetry for internal radiation therapy can be especially challenging, given the heterogeneity of patient anatomy, tumor anatomy, and source deposition. Internal radiotherapy sources such as nanoparticles and monoclonal antibodies require high resolution imaging to accurately model the heterogeneous distribution of these sources in the tumor. The resolution of nucl...

stroke scales can be classified as clinicometric scales and functional impairment, handicap scales. all studies describing stroke scales were reviewed by internet searching engines with the final search performed on january 1, 2013. the following string of keywords was entered into search engines; stroke, scale, score and disability. despite advantages of modified national institute of health s...

This paper presents a simple model of computational design creativity evaluation, presenting its components with rationale. Components are linked to recent research. The model assumes that the product, not the process, is being evaluated, and that evaluation is done by comparison with descriptions of existing products using a set of aspects that each suggest creativity. Not every evaluation wil...

PURPOSE Malignant sinonasal tumors are clinically challenging due to their proximity to vital structures and their diverse histogenesis and biological behavior. To date, no animal models accurately reflect the clinical behavior of these malignancies. We developed an orthotopic murine model of sinonasal malignancy that reproduces the intracranial extension, bony destruction, and spread along neu...

In this paper we give the details of the numerical solution of a three-dimensional multispecies diffuse interface model of tumor growth, which was derived in (Wise et al., J. Theor. Biol. 253 (2008)) and used to study the development of glioma in (Frieboes et al., NeuroImage 37 (2007) and tumor invasion in (Bearer et al., Cancer Research, 69 (2009)) and (Frieboes et al., J. Theor. Biol. 264 (20...

Tumor growth prediction, a highly challenging task, has long been viewed as a mathematical modeling problem, where the tumor growth pattern is personalized based on imaging and clinical data of a target patient. Though mathematical models yield promising results, their prediction accuracy may be limited by the absence of population trend data and personalized clinical characteristics. In this p...

Brain tumor is a very harmful disease for human being. A tumor is a mass of tissue that's formed by an accumulation of abnormal cells. The location of tumors in the brain is one of the factors that determine how a brain tumor effects an individual's functioning. Image processing is an active research area in which medical image processing is a highly challenging field. For medical diagnosis of ...

Prognosis of metastatic breast cancer is very poor which urges the necessity to develop novel potential drug candidates. We assessed two compounds with tri-aryl structures (A and B) for their potency to reduce primary breast tumor growth and lung metastasis in 4T1 mice model. MTT assay, 4T1 mammary mouse model and immunohistochemistry experiments were used in this study. In vitro results exhibi...