Tirapazamine (TPZ) is a hypoxia-selective bioreductive drug currently in Phases II and III clinical trials with both radiotherapy and chemotherapy. The response of tumors to TPZ is expected to depend both on the levels of reductive enzymes that activate the drug to a DNA-damaging and toxic species and on tumor oxygenation. Both of these parameters are likely to vary between individual tumors. I...

Objective(s): This study was designed to assess defect detectability in positron emission tomography (PET) imaging of abdominal lesions. Methods: A National Electrical Manufactures Association International Electrotechnical Commission phantom was used. The simulated abdominal lesion was scanned for 10 min using dynamic list-mode acquisition method. Images, acquired with scan duration of 1-10 mi...

Background: To evaluate computed tomography (CT) and magnetic resonance imaging (MRI) fusion images for delineating gross tumor volume (GTV) in three-dimensional conformal radiotherapy (3D-CRT) of nasophanrygeal carcinoma (NPC), and compare treatment outcomes between CT- and CT+MRI-based targets. Materials and Methods: A total of 120 NPC patients treated with 3D-CRT were included, in which, 60 ...

Many studies have established the fact that cortisol and cortisone inhibit the growth of tumors of lymphoid origin (8,19, 20, 23, 24). However, the effect of these steroids on other types of tumors is by no means certain. In most instances in which any effect on tumor growth is observed, these corticoids have been found to inhibit the tumors, but there have also been a few reports (5, 26) of en...

leydig stromal cell tumor is a rare ovarian tumor that belongs to the group of sex-cord stromal tumors. they produce testosterone leading to hyperandrogenism. we present a 41yr old woman with symptoms of virilization and a mass of right adenex via ultra sonography, and a rise of total and free serum testosterone. an ovarian source of androgen was suspected and a surgery performed. a diagnosis o...

this study investigates the atmospheric circulation associated with extreme rainfall events over the coastal west africa. the rainfall data of this study were obtained from the global precipitation climatology centre (gpcc), spanning from 1981 to 2010. the atmospheric datasets were also obtained from the era-interim reanalysis. the study employed the z-index to categorize dry and wet years into...

we report occurrence of a rare case of giant cell tumor (gct), in a 28-year old woman, arising from anterior arc of right 6 th rib during pregnancy. it progressed rapidly during breast-feeding period, mimicking malignant bone tumor at delayed presentation.

We estimated reader-dependent variability of region of interest (ROI) analysis and evaluated its impact on preclinical quantitative molecular imaging. To estimate reader variability, we used five independent image datasets acquired each using microPET and multispectral fluorescence imaging (MSFI). We also selected ten experienced researchers who utilize molecular imaging in the same environment...

Summer maize (Zea mays L.) is one of the dominant crops in the North China Plain (NCP). Its growth is greatly influenced by the spatial-temporal variation of climatic variables, especially solar radiation, temperature and rainfall. The WOFOST (version 7.1) model was applied to evaluate the impact of climatic variability on summer maize yields using historical meteorological data from 1961 to 20...