By its frequency, colorectal cancer (CRC) has become a serious public health problem. BAT25 marker is included in the panel of five markers dedicated to the diagnosis of CCR microsatellite instability. The objective of this study was to evaluate the polymorphism and genetic diversity of the BAT25 marker in CRC cases in Senegal. This prospective study was performed on 22 CRC patients. After DNA ...

Introduction: In external beam radiotherapy each effort is done to deliver 3D dose distribution onto the tumor volume uniformly, while minimizing the dose to healthy organs at the same time. Radiation treatment of tumors located at thorax region such as lung and liver has a challenging issue during target localization since these tumors move mainly due to respiration. There are...

Positron emission tomography (PET) imaging using 2-deoxy-2-[F-18]fluoro-D-glucose (FDG) has proven valuable in the diagnosis, staging and restaging for many cancers. However, its application for liver cancer has remained limited owing in part to the relatively high background uptake of the tracer in the liver plus the significant variability of the tumor specific uptake in liver cancer among pa...

inflammatory myofibroblastic tumor (imt) is an aggressive benign mass that may arise from various tissues and organs with a great variability of histological and clinical appearances. due to variable and nonspecific imaging findings, diagnosis of imt is not obtained before surgery. the aim of this paper is to present ct and mri findings during four-year follow-up of complete, spontaneous regres...

Knowledge of intrinsic tumor heterogeneity is vital for understanding of tumor progression mechanisms as well as for providing efficient treatments. In situ proteomic profiling of tumors is a powerful technology with potential to enhance our understanding of tumor biology, but sources of variability due to patient and tumor heterogeneity are poorly understood and are the topic of this investiga...

positron emission tomography (pet) imaging using 2-deoxy-2-[f-18]fluoro-d-glucose (fdg) has proven valuable in the diagnosis, staging and restaging for many cancers. however, its application for liver cancer has remained limited owing in part to the relatively high background uptake of the tracer in the liver plus the significant variability of the tumor specific uptake in liver cancer among pa...

UNLABELLED PET can be used to monitor response during chemotherapy and assess biologic target volumes for radiotherapy. Previous simulation studies have shown that the performance of various automatic or semiautomatic tumor delineation methods depends on image characteristics. The purpose of this study was to assess test-retest variability of tumor delineation methods, with emphasis on the effe...

Introduction: Several studies have investigated differences in quantitative morphological features between benign and malignant breast tumors, as assessed by dynamic contrast enhanced-MRI (DCE-MRI); however, very little information is available on the extent of such differences between certain subgroups of malignant tumors, such as hormone receptor positive and negative tumors. Such information...

PURPOSE The aim of the study was to evaluate the inter- and intrapatient variability of positron emission tomography (PET) measurements of perfusion in advanced solid cancers. EXPERIMENTAL DESIGN Thirty-seven patients with predominantly intra-abdominal tumors underwent PET imaging using inhaled C15O2. Repeat data were obtained by scanning five patients twice, 1 week apart, with no intervening...

Somatic genetic analysis of tumors and metastases has yielded a plethora of information regarding genes associated with cancer progression. However, somatic alterations in tumor cells are only one source of variability. Genetic polymorphism may also play a significant role in person-to-person variability in metastasis frequency, raising the intriguing possibility that some individuals could be ...