Let (X,d,μ) be a space of homogeneous type in the sense Coifman and Weiss, i.e. d is quasi metric on X μ positive measure satisfying doubling condition. Suppose that u v are two locally finite Borel measures (X,d,μ). Subject to pair weights side condition, we characterize boundedness Calderón–Zygmund operator T from L2(u) L2(v) terms A2 condition testing conditions. For every cube B⊂X, have fol...

BACKGROUND Protein tyrosine phosphatases (PTPs) in conjunction with protein tyrosine kinases (PTKs) regulate cellular processes by posttranslational modifications of signal transduction proteins. PTP nonreceptor type 1B (PTP-1B) is an enzyme of the PTP family. We have previously shown that hypoxia induces an increase in activation of a class of nonreceptor PTK, the Src kinases. In the present s...

The striatonigral projection is a striatal output pathway critical to motor control, cognition, and emotion regulation. Its axon terminals in the substantia nigra pars reticulata (SNr) express a high level of serotonin (5-HT) type 1B receptors (5-HT(1B)Rs), whereas the SNr also receives an intense 5-HT innervation that expresses 5-HT transporters, providing an anatomic substrate for 5-HT and se...

spectral data from E. coli, S. aureus and P. aeruginosa infected C57BL/6 wild-type mice, showing the separation between samples along the type of infection (Fig.1A) and scores plot of the metabolite concentrations found in TLR4 deficient mice with LPS treatment and E. coli infection (Fig.1B). Two components encapsulate 82 % (A) and 90 % (B) of the interclass variation. Fig.2: The coefficient pl...

A working structural model of penicillin-binding protein 1B (PBP 1B) from Escherichia coli derived from previous data consists of a highly charged aminoterminal cytoplasmic tail, a 23-amino-acid hydrophobic transmembrane anchor, and a 758-amino-acid periplasmic domain. Using an engineered thrombin cleavage site, we have investigated the solubility properties of the periplasmic domain of PBP 1B....

Cardiac-specific overexpression of wild-type alpha(1B)-adrenergic receptors (alpha(1B)-AR) in mice predisposes to dilated cardiomyopathy and sudden death. Although alpha-adrenergic stimulation is thought to contribute to induction of arrhythmias in heart failure, the electrophysiological consequences of chronic alpha(1)-adrenergic activation have not been clearly defined. Thus we characterized ...