BACKGROUND Hypovitaminosis D is unrecognized and remarkably common in geriatric patients, with various clinical manifestations. The purpose of this study was to prospectively assess the vitamin D (VD) status in newly admitted psychogeriatric patients, and to study the correlation of VD status with indicators of calcium metabolism. METHODS A valid VD sample, as measured by serum 25-hydroxyvita...

Acid secretion in gastric parietal cells requires highly coordinated membrane transport and vesicle trafficking. Histologically, consensus defines acid secretion as the ratio of the volume density (Vd) of canalicular and apical membranes (CAMs) to tubulovesicular (TV) membranes, a value which varies widely under normal conditions. Examination of numerous achlorhydric mice made it clear that thi...

STUDY DESIGN We tested the hypothesis that maximal exercise performance in subjects with interstitial lung disease (ILD) is limited by respiratory factors. Assuming this is so, ventilatory stimulation by added dead space (VD) should impair exercise capacity. METHODS Six subjects with ILD each underwent three maximal incremental exercise studies on a bicycle ergometer; control 1, added VD, and...

Background Hashimoto's thyroiditis (HT) is a common cause of thyroid diseases in children and the role of vitamin D (VD) is controversial. Therefore, the aim of this study was to investigate the influence of VD therapy on HT in children with hypovitaminosis D.<br...

Hydroxychloroquine (HCQ) dosage required to reach circulating levels that inhibit SARS-Cov-2 are extrapolated from pharmacokinetic data in non-COVID-19 patients. We performed a population-pharmacokinetic analysis 104 consecutive COVID-19 hospitalized patients (31 intensive care units, 73 medical wards, n = 149 samples). Plasma HCQ concentration were measured using high performance liquid chroma...

Objective: IGF1 plays a key modulatory role in promoting angiogenesis, as well as muscle and nerve regeneration. Although systemic administration of IGF1 improved urinary sphincter function in vivo, this therapy has several pitfalls, including limited effects due to the short half-life of IGF1 and potential dose-related toxicity. It is important to use a delivery system that slowly releases sui...

SHIKHA CHUGH*, KRISHNA DEB BARMAN**, KHUSBHU GOEL* & VIIJAY KUMAR GARG*** *Senior Resident, Department of Dermatology & VD, Maulana Azad Medical College, Bahadur SahZafar Marg, New Delhi 110002, India **Associate Professor, Department of Dermatology & VD, Maulana Azad Medical College, Bahadur SahZafar Marg, New Delhi 110002, India ***Dir. Professor & Head, Department of Dermatology & VD, Maulan...

Temozolomide (TMZ), an alkylating agent, is recommended as the initial treatment for high-grade glioblastoma. TMZ is widely used, but its short half-life and the frequency of tumor resistance limit its therapeutic efficacy. In the present study, the anticancer effect of vitamin D (VD) combined with TMZ upon glioblastoma was determined, and the underlying mechanism of this effect was identified....

We investigated the expression levels and clinical significance of S100β protein in patients with vascular dementia (VD) after basal ganglia hemorrhage. From June 2014 to December 2015, in 138 patients with basal ganglia hemorrhage, we carried out the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) in patients on the day before the operation, the day after the oper...