Treatment with solvent/detergent is a widely used method for ensuring the virus safety of plasma products. In the present study, virus inactivation by a novel solvent/detergent combination, i.e. TnBP (tri-n-butyl phosphate) and polysorbate 20 during the manufacture of the factor VIII/VWF concentrate Optivate has been investigated. The inactivation of most enveloped viruses was rapid, i.e. > 5 l...

The risk and importance of transfusion-transmitted hepatitis E virus (TT-HEV) infections by contaminated blood products is currently a controversial discussed topic in transfusion medicine. The infectious dose, in particular, remains an unknown quantity. In the present study, we illuminate and review this aspect seen from the viewpoint of a blood donation service with more than 2 years of exper...

Plasmapheresis, which is defined as the removal of plasma, can be either "adjusted plasma" or “exchange of plasma”. The former is defined as selective withdrawal of certain (un)-pathological plasma components in different ways such as perfusion and then returning the remained donor plasma to him, the latter is non-selective removal of all components of plasma to provide blood products for injec...

in this study the plasma levels of lipid peroxidation (lp) products, protein carbonyls and antioxidant capacity of plasma as judged by ferric reducing ability of plasma (frap assay) were compared in adult and weanling rats treated with vitamin k1 phylloquinone).

In this review, inactivation and activation of microorganisms using fine bubbles are introduced. the first chapter, we introduce domestic overseas research trends sterilization methods ozone plasma. second focus on researches such as cleaning lipstick at cosmetic application, generation plasma-activated microbubbles for fresh foods verification underwater plasma characteristics under bubble dis...

Congenital deficiency Hereditary angioedema Hereditary deficiency (emphysema, cirrhosis) ? Acquired deficiency states Most therapeutic plasma products are manufactured from pools of plasma derived from many thousands of donors. Although strenuous efforts are being made to achieve self sufficiency, the United Kingdom is still substantially dependent on imported products that originate mainly fro...

Viral inactivation and adhesion-aggregation in water are often studied as separate phenomena. When the focus is placed on viral adhesion-aggregation, inactivation is neglected because the phenomena under investigation occur over a short period measured in days. When viral inactivation is studied, adhesion-aggregation phenomena are considered to be negligible because viral survival is traced ove...

The processing of insects is paramount to deliver safe and high quality raw materials, ingredients products for large-scale food feed applications. Depending upon the nature initial material desired end product, pathways vary may include several unit operations currently already used in processing. Insect can involve harvesting, pre-processing, decontamination, further processing, packaging sto...