expression of receptor tyrosine kinase ror1 in a wide variety of cancers has emerged as a new era focusing on targeting this receptor in cancer therapy. our preliminary re-sults indicate the presence of a truncated transcript of ror1 in tumor cells. the trun-cated ror1 encompasses extracellular and transmembrane domains, lacking catalytic kinase domain (ror1-ecd). as enzyme activity is highly d...

A simple, clean, and environmentally benign three-component process for the synthesis of 2-amino-4Hchromenes using [mim]Cl, as an efficient catalyst under solvent-free conditions are described. A wide range of aromatic aldehydes easily undergoes condensations with 1-naphthol and malononitrile under solvent-free conditions to afford the desired products of good purity in excellent yields. Taking...

This paper describes the methodology of an intelligent agent for building a self-adaptive course on the Web. An important task, therefore, is to combine adaptability with the learner-driven course in order to get a self-adaptive mechanism. For this, we have suggested a new structure for a web course. Based on this structure, we have suggested a new method to evaluate the granularity level of ea...

This document describes extensions to the Intermediate System to Intermediate System (IS-IS) protocol to support optimal routing within a two-level domain. The IS-IS protocol is specified in ISO 10589, with extensions for supporting IPv4 (Internet Protocol) specified in RFC 1195. This document replaces RFC 2966. This document extends the semantics presented in RFC 1195 so that a routing domain ...