Brucella abortus is a facultative intracellular bacterial pathogen that causes abortion in domestic animals and undulant fever in humans. IFN-γ, IL-12, and CD8+ T lymphocytes are important components of host immune responses against B. abortus. Herein, IFN-γ and IL-12/β2-microglobulin (β2-m) knockout mice were used to determine whether CD8+ T cells and IL-12-dependent IFN-γ deficiency would be ...

Background: Human colorectal cancer cells overexpress carcinoembryonic antigen (CEA). CEA is a glycoprotein which has shown to be a promising vaccine target for immunotherapy against colorectal cancer. Objective: To design a DNA vaccine harboring CEA antigen and evaluate its effect on inducing immunity against colorectal cancer cells in tumor bearing mice. <str...

Experimental autoimmune encephalomyelitis (EAE) is mediated by Th1 and Th17 cells. Invariant NKT (iNKT) cells prevent EAE in an IL-4-, IL-10-, and IFN-γ-dependent manner. However, which of the iNKT cell-produced cytokines regulates the Th1 or Th17 response in EAE remains unclear. Wild-type B6 and Jα18(-/-) mice were immunized with MOG(35-55) peptide to address this issue. Clinical scores for EA...

Abstract Background To explore the differences of multiple cytokines secretion based on QuantiFERON-TB Gold Plus(QFT-Plus)antigens stimulation, and to screen with potential differentiate tuberculosis infection status. Methods Twenty patients diagnosed microbiologically active tuberculosis(ATB)in Peking Union Medical College Hospitaland Beijing Chest Hospital from February April 2022 were enroll...

background : cytokines produced by different subsets of t cells are the key mediators to adjust the quality of immune responses. despite evidence of induction of an immune reaction against tumors such as breast cancer, not all responses are protective. in this study we attempt to evaluate the expression profile of several cytokines from the t helper 1 and 2 subsets in blood cells from patients ...

interleukin (il)-17-producing t helper (th)-17 cells have recently been explained as a distinct population  of  cd4+  t  cells which play an important  role in immunity against infectious agents. establishment of persistent phenotype of th17 cells and recognition of lineage-deviating factors are of most attractive goals in modern researches in immunology. although  il-6  and  tgf-β  are  freque...

Introduction It has been previously identified that levels of peripheral inflammatory proteins, such as cytokines, are altered in people with schizophrenia spectrum disorders (SSD). Objectives As there is considerable inconsistency the literature respect to how profiles differ between acute and chronic stages SSD, a systematic review network meta-analysis was performed. Methods Records from CIN...

background & aim: multiple sclerosis(ms) is the most common inflammatory disease of central nervous system which is caused by an autoimmune process leading to destruction of myelin sheath. in this disease, cd4+ t–lymphocytes, mostly of th1 phenotype, play important roles in destruction of neuronal tissues.  because of the probable etiologic participation of ebv virus in immunopathogenesis of ms...

the identification of early markers of atopy in cord blood of newborns at delivery may offer prediction of future allergic sensitization. the aim of this study was to evaluate the relationship between cord blood interleukin-13 (il-13) and interferon-gamma (ifn-γ) and development of allergic diseases during the first five years of life. umbilical cord blood samples were collected at the time of ...

Background: The use of narcotics such as opium exposes addicts as susceptible targets of different diseases so that they might easily be exposed to different diseases such as fungal infections. The present study aimed to investigate the effects of addiction to opium and fungal infection on plasma levels of certain cytokines including interleukin-4 (IL-4), IL-6, IL-17, Interferon gamma (IFN-γ) a...