It has been shown that osteopontin (OPN) plays a pivotal role in the pathogenesis of rheumatoid arthritis (RA). However, the molecular mechanism of OPN action is yet to be elucidated. Splenic monocytes obtained from arthritic mice exhibited a significant capacity for cell migration toward thrombin-cleaved OPN but not toward full-length OPN. Migratory monocytes expressed alpha9 and alpha4 integr...

The nucleolar PeBoW-complex, consisting of Pes1, Bop1 and WDR12, is essential for cell proliferation and processing of ribosomal RNA in mammalian cells. Here we have analysed the physical and functional interactions of Pes1 deletion mutants with the PeBoW-complex. Pes1 mutants M1 and M5, with N- and C-terminal truncations, respectively, displayed a dominant-negative phenotype. Both mutants show...

We consider the thermodynamics of the near-extremal NS5-brane in type IIA string theory. The central tool we use is to map phases of six-dimensional Kaluza-Klein black holes to phases of near-extremal M5-branes with a transverse circle in eleven-dimensional supergravity. By S-duality these phases correspond to phases of the near-extremal type IIA NS5-brane. One of our main results is that in th...

This paper is concerned with the construction of intervals of computably enumerable degrees in which the lattice M5 (see Figure 1) cannot be embedded. Actually, we construct intervals I of computably enumerable degrees without any weak critical triples (this implies that M5 cannot be embedded in I, see Section 2). Our strongest result is that there is a low2 computably enumerable degree e such ...

We study the properties of an exact multi-membrane solution in seven-dimensional maximal SO(5)-gauged supergravity. Unlike previously known multi-centered solutions, the present one is asymptotically anti-de Sitter. We show that this multi-membrane configuration preserves only a quarter of the supersymmetries. When lifted to eleven dimensions, this solution is interpreted as a set of open membr...

We construct an explicit supergravity solution for a configuration of localized D4brane ending on a D6-brane, restricted to the near horizon region of the latter. We generate this solution by dimensionally reducing the supergravity solution for a flat M5-brane in R1,7 × C/ZN with the M5-brane partially embedded in C/ZN . We describe the general class of localized intersections and overlaps whos...

Using a recently constructed M5-brane world-volume action, we demonstrate that wrapping the M5-brane on K3 gives the heterotic string in seven dimensions. To facilitate the comparison, a new version of the world-sheet action for the Naraincompactified heterotic string, with manifest T duality invariance, is formulated. Work supported in part by the U.S. Dept. of Energy under Grant No. DE-FG03-9...

We consider the low-energy limit of the two-dimensional theory on multiple M2-branes suspended between a flat M5-brane and a curved M5brane. We argue that it is described by an N=(2, 2) supersymmetric LandauGinzburg model with the superpotential determined by the shape of the curved M5-branes, which flows in the low-energy limit to a Kazama-Suzuki coset model. We provide evidence by studying gr...