An adaptive maximum-likelihood procedure (MLP), typically used for threshold measurements in psychoacoustics, was adopted for the measurement of speech intelligibility, with the use of the modified rhyme test (MRT) [1]. The advantage of the MLP over the fixed step up-down adaptive procedures usually employed in adaptive speech intelligibility tests is that the MLP imposes no restrictions on the...

Phosphatidylinositol bisphosphate (PIP2) regulates epithelial sodium channel (ENaC) open probability. In turn, myristoylated alanine-rich C kinase substrate (MARCKS) protein or MARCKS-like protein 1 (MLP-1) at the plasma membrane regulates the delivery of PIP2 to ENaC. MARCKS and MLP-1 are regulated by changes in cytosolic calcium; increasing calcium promotes dissociation of MARCKS from the mem...

Heart failure and dilated cardiomyopathy develop in mice that lack the muscle LIM protein (MLP) gene (MLP(-/-)). The character and extent of the heart failure that occurs in MLP(-/-) mice were investigated using echocardiography and in vivo pressure-volume (P-V) loop measurements. P-V loop data were obtained with a new method for mice (sonomicrometry) using two pairs of orthogonal piezoelectric...

Dr. David Shahian Lahey Clinic Burlington, MA 01805 Experiments demonstrated that sigmoid multilayer perceptron (MLP) networks provide slightly better risk prediction than conventional logistic regression when used to predict the risk of death, stroke, and renal failure on 1257 patients who underwent coronary artery bypass operations at the Lahey Clinic. MLP networks with no hidden layer and ne...

The biliary excretion of several organic anions is mediated by the canalicular multispecific organic anion transporter (cMOAT), which is hereditarily defective in mutant rats such as Eisai hyperbilirubinemic rats (EHBR). In addition, using a kinetic study with isolated canalicular membrane vesicles, we recently suggested the presence of ATP-dependent organic anion transporter(s) other than cMOA...

The objective of this study is to develop artificial neural network (ANN) models, including multilayer perceptron (MLP) and Kohonen self-organizing feature map (KSOFM), for spatial disaggregation of areal rainfall in the Wi-stream catchment, an International Hydrological Program (IHP) representative catchment, in South Korea. A three-layer MLP model, using three training algorithms, was used to...