Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that regulate gene expression of lipoprotein lipase (LPL) in liver and adipose tissue. We examined the direct effect of PPAR-alpha ligands on LPL catalytic activity in cultured cardiomyocytes from adult rat heart. After overnight culture (16 h), 1 microM Wy-14643 and 10 microM BM-17.0744 decreased tot...

Assessing land use change and its impacts on ecosystem services is of great significance for optimizing management enhancing sustainability. This study explores changes their five typical services, namely grain production (GP), water yield (WY), soil conservation (SC), habitat quality (HQ), carbon sequestration (CS), during 1990–2020 using the Integrated Valuation Ecosystem Services Trade-offs ...

Exploring the responses of ecosystem services to climate change is an essential prerequisite for understanding global impact on terrestrial ecosystems and their modeling. This study first evaluated including net primary productivity (NPP), soil conservation (SC) water yield (WY), factors precipitation, temperature, solar radiation from 2000 2020 Loess Plateau, then analyzed relationships thresh...

Although Francisella tularensis is considered a monomorphic intracellular pathogen, molecular genotyping and virulence studies have demonstrated important differences within the tularensis subspecies (type A). To evaluate genetic variation within type A strains, sequencing and assembly of a new subtype A.II genome was achieved for comparison to other completed F. tularensis type A genomes. In c...

Inositol 1,4,5-trisphosphate (IP3) regulates a host of biological processes from egg activation to cell death. When IP3-specific receptors (IP3Rs) bind to IP3, they release calcium from the ER into the cytoplasm, triggering a variety of cell type- and developmental stage-specific responses. Alternatively, inositol polyphosphate kinases can phosphorylate IP3; this limits IP3R activation by reduc...

Sheikh K, Camejo G, Lanne B, Halvarsson T, Landergren MR, Oakes ND. Beyond lipids, pharmacological PPAR activation has important effects on amino acid metabolism as studied in the rat. Am J Physiol Endocrinol Metab 292: E1157–E1165, 2007. First published December 12, 2006; doi:10.1152/ajpendo.00254.2006.—PPAR agonists have been characterized largely in terms of their effects on lipids and gluco...