background: mesenchymal stem cells (mscs) possess a wide range of immunomodulatory functions mostly in immune cells including dendritic cells (dcs). dcs are the key cells in the immune response and play an important role in initiating cell-mediated immunity. objective: to evaluate the immunomodulatory effects of mscs supernatant on maturation and function of dcs. methods: bone marrow derived mi...

صلاخلا ــ ة : مت ةقرولا هذه يف ءاشنإ يف هدعاسملل مدقتم ماظن بناوج ذيفنتو ميمصت ضرع قتو و مي ءادأ حيحصت تارفش لأا ءاطخ ةليلق لا ةناتم ، ةينبم ىلع ءوفاكتلا رايتخا . موقي امه نيتيسيئر نيتفيظوب ةساردلا هذه يف مدقتملا ماظنلا : 1 ادأ باسحل ةيزاوتملا هاآاحملا ء تارفش حيحصت لأا ءاطخ ةليلق نمزب ةفاثكلا ادج ريصق ةنراقم ةمظنأب ةاآاحملا ةدوجوملا . 2 ةليلق ءاطخلأا حيحصت تارفشو فعضلا قطانم صحف نع ة...

Objective(s): In addition to pro-inflammatory role, dendritic cells (DCs) can also be anti-inflammatory when they acquire tolerogenic phenotype. In this study we tested the role of CD40 and IL-23p19 in antigen presenting function of bone marrow-derived DCs (BMDCs) by comparing BMDCs derived from CD40 knockout (CD40KO-DCs) and IL-23p19 (IL-23p19KO-DCs) knockout mice wit...

background: dendritic cells (dcs) are professional antigen presenting cells (apcs), and there is considerable interest in their application as a cellular adjuvant for cancer immunotherapy.  previous studies indirectly demonstrated that dcs were able to take up tumor lysate (crude soluble tumor antigens) and also cross-present tumor associated antigens (taa) which elicits anti-tumor immune respo...

Background: Dendritic cells (DCs) are professional antigen presenting cells (APCs), and there is considerable interest in their application as a cellular adjuvant for cancer immunotherapy.  Previous studies indirectly demonstrated that DCs were able to take up tumor lysate (crude soluble tumor antigens) and also cross-present tumor associated antigens (TAA) which elicits anti-tumor immune respo...