نتایج جستجو برای: کشف mirna

تعداد نتایج: 32753  

ژورنال: علوم دامی ایران 2017

تعادل منفی انرژی (NEB) در گاوهای شیری پرتولید در چند هفتة نخست پس از زایمان رخ می­دهد و به دلیل اثرگذاری منفی بر باروری و سلامتی اهمیت اقتصادی زیادی در گله­های گاو شیری دارد. بنابراین، شناسایی هر چه بهتر سازوکارهای تنظیمی مؤثر در این اختلال سوخت‌وسازی (متابولیکی) اهمیت دارد. یکی از عامل‌های تنظیمی مؤثر در NEB، miRNAها هستند. به‌رغم اهمیت NEB، سازوکارهای تنظیمی مربوط به miRNAها در این دوره به‌خو...

Aim 3,4-methylenedioxymethamphetamine (MDMA) is one of the most widespread illegal drugs, used particularly by young people in the 15-34 age group. MicroRNAs (miRNAs) are endogenously synthesized, non-coding and small RNAs that post-transcriptionally regulate their target genes’ expression by inhibiting protein translation or degradation. miRNAs are increasingly implicated in drug-related...

میکروآرنا‎ها (miRNA) یک رده از RNA‎های تنظیم‎کننده کوچک درونی و غیرکدکننده پروتئینی که متشکل از حدود 18-22 نوکلئوتید بوده و تنظیم بیان ژن را در سطح رونویسی و پس از رونویسی ژن بر عهده دارند و طبق تحقیقات انجام شده نقش‎های اساسی در فرایندهای نموی، زمان گلدهی و پاسخ به تنشهای زیستی و غیرزیستی ایفا می‎کنند. تاکنون روش‎های متفاوتی برای شناسایی miRNA‎ها، معرفی شده است که عبارتند از: روش نورترن بلات، ...

2013
Zhigang Hu Wen-Jun Shen Yuan Cortez Xudong Tang Li-Fen Liu Fredric B. Kraemer Salman Azhar

BACKGROUND Given the emerging roles of miRNAs as potential posttranscriptional/posttranslational regulators of the steroidogenic process in adrenocortical and gonadal cells, we sought to determine miRNA profiles in rat adrenals from animals treated with vehicle, ACTH, 17α-E2 or dexamethasone. Key observations were also confirmed using hormone (Bt2cAMP)-treated mouse Leydig tumor cells, MLTC-1, ...

پایان نامه :وزارت علوم، تحقیقات و فناوری - پژوهشگاه ملی مهندسی ژنتیک وزیست فناوری 1392

هموفیلی b یا کریسمس از بیماریهای مسیر انعقادی است که درنتیجه اختلال یا کمبود فاکتور9 حاصل میشود. درمان این بیماری مانند بسیاری از بیماری های سیستمیک دیگر به روش جایگزین درمانی انجام می گیرد. فاکتور 9 در طی مراحل بلوغ خود متحمل برخی تغییرات پس از ترجمه می شود. از جمله این تغییرات کربوکسیله شدن 12 اسید آمینه گلوتامیک اسید است. کربوکسیلاسیون توسط آنزیم گاما کربوکسیلاز در شبکه آندوپلاسمیک انجام می ...

Journal: :avicenna journal of medical biotechnology 0

micrornas (mirnas) are short rna molecules which bind to target mrnas, resulting in translational repression and gene silencing and are found in all eukaryotic cells. approximately 2200 mirna genes have been reported to exist in the mammalian genome, from which over 1000 belong to the human genome. many major cellular functions such as development, differentiation, growth, and metabolism are kn...

ژورنال: :thrita 0
bahareh moradi najafabad branch, islamic azad university, najafabad, isfahan, iran hossein tabatabaeian genetics division, biology department, faculty of sciences, university of isfahan, isfahan, iran samira sadeghi genetics division, biology department, faculty of sciences, university of isfahan, isfahan, iran mansoureh azadeh najafabad branch, islamic azad university, najafabad, isfahan, iran kamran ghaedi cellular and molecular biology division, biology department, faculty of sciences, university of isfahan, isfahan, iran; cellular and molecular biology division, biology department, faculty of sciences, university of isfahan, isfahan, iran. tel: +98-3137932479, fax: +98-3137932456

conclusions rs1595065 could be recommended as a risk factor in regulating her4 expression and affecting her2 positivity incidence among bc patients. methods overall, 156 patients and controls were genotyped using rflp-pcr. armitage test for trend was utilized to investigate the association between rs1595065 and susceptibility to bc. the possible change in the interaction between rs1595065 and m...

ژورنال: :gene, cell and tissue 0
fatemeh shakarami department of biology, guilan university, rasht, ir iran reza mirfakhraie department of medical genetics, shahid beheshti university of medical sciences, tehran, ir iran shohreh zare karizi department of biology, varamin pishva branch, islamic azad university, pishva, varamin, ir iran; department of biology, varamin pishva branch, islamic azad university, pishva, varamin, ir iran. tel: +98-9125953602 hanieh zare department of biology, varamin pishva branch, islamic azad university, pishva, varamin, ir iran

materials and methods the case and control groups were studied for the association between polymorphism of mir17hg and recurrent pregnancy loss in iranian females. one-hundred patients with recurrent abortions (at least two) as cases and one-hundred healthy female with two or more normal term deliveries and without a history of abortion were selected as controls. total genomic dna was isolated ...

Journal: :Molecular biology and evolution 2012
Wanjun Gu Xiaofei Wang Chuanying Zhai Xueying Xie Tong Zhou

Synonymous codons are widely selected for various biological mechanisms in both prokaryotes and eukaryotes. Recent evidence suggests that microRNA (miRNA) function may affect synonymous codon choices near miRNA target sites. To better understand this, we perform genome-wide analysis on synonymous codon usage around miRNA target sites in four plant genomes. We observed a general trend of increas...

2017
Joseph J. Nalluri Debmalya Barh Vasco Azevedo Preetam Ghosh

Decoding the patterns of miRNA regulation in diseases are important to properly realize its potential in diagnostic, prog- nostic, and therapeutic applications. Only a handful of studies computationally predict possible miRNA-miRNA interactions; hence, such interactions require a thorough investigation to understand their role in disease progression. In this paper, we design a novel computation...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید