The search for new molecules to fight Pseudomonas aeruginosa is of paramount importance. Carbon monoxide (CO) is known to act as an effective inhibitor of the respiratory chain in P. aeruginosa, but the practical use of this gas as an antibacterial molecule is hampered by its toxicity and difficulty to manipulate. Here, we show that a water-soluble CO releaser (CORM-3) possesses bactericidal pr...

Carbon monoxide (CO) has shown various physiological effects including anti-inflammatory activity in several diseases, whereas the therapeutic efficacy of CO on sepsis-induced acute kidney injury (AKI) has not been reported as of yet. The purpose of the present study was to explore the effects of exogenous CO on sepsis-induced AKI and nucleotide-binding domain-like receptor protein 3 (NLRP3) in...

Carbon monoxide (CO) is a physiological messenger with diverse functions in the kidney, including controlling afferent arteriole tone both directly and via tubuloglomerular feedback (TGF). We have reported that CO attenuates TGF, but the mechanisms underlying this effect remain unknown. We hypothesized that CO, acting via cGMP, cGMP-dependent protein kinase, and cGMP-stimulated phosphodiesteras...

Future Internet design demands revolutionary approaches unfettered by legacy constraints and concepts. This paper presents a clean-slate Concern-Oriented Reference Model (CORM) for architecting future computer networks based on novel network design principles. CORM realizes the network as a software-dependent complex system. It defines the network design space in terms of function, structure an...

in order to investigate the effects of nitrogen application rates and different planting beds on yield and yield components of garlic (allium sativum l.), a field experiment was conducted as split plot based on a randomized complete block design with four replications at the agricultural research station, azad university of torbat-e-jam, iran, during 2009-2010. three nitrogen application rates ...

In order to test the feasibility of computer simulation in field maize planting, the selection of the method of single seed precise sowing in maize is studied based on the quadratic function model Y = A×(D-Dm)2+Ym, which depicts the relationship between maize yield and planting density. And the advantages and disadvantages of the two planting methods under the condition of single seed sowing ar...

in order to investigation some soil characteristics and filed age effects on flower and corm yield of saffron, an experiment was conducted as factorial based on complete randomized design with five replications in two regions of neyshabur during growing season 2009-2010. treatments were included different filed ages (2, 4 and 6 years) and two geographical regions (eshagh abad and soltan abad). ...

biofertilizers are natural inputs that can be applied as complement or substituent of chemical fertilizers in sustainable agriculture. effects of n and p bio- and chemical fertilizers on growth indices of maize (zea mays l.) was studied on 2008 in shushtar, iran, based an as a factorial experiment based on completely randomized block design with three replications. treatments consisted four lev...

PURPOSE The main aim of the experiment is to examine the effect of CORM-2, a donor of carbon monoxide (CO), on oxidative stress in human plasma in vitro. In addition, it examines the effects of CORM-2 on the hemostatic parameters of plasma: the activated partial thromboplastin time (APTT), thrombin time (TT) and prothrombin time (PT). METHODS Human plasma was incubated for 5-60 min with diffe...