Abstract Pumpkin ( Cucurbita pepo L. ) seeds are enriched in bioactive compounds having functional properties. The aim of this study was to analyze the pumpkin seed proteins (PSP) effects on insulin resistance, oxidative stress damage and inflammation rats with high fructose-induced metabolic syndrome. Twenty four male Wistar rats, fed isoenergetic diets supplemented with: (1) 20% casein (C); (...

Objective: Hypertension is a common component of metabolic syndrome (MetS). Some studies showed that L-arginine reduced the blood pressure (BP) .Therefore this study was designed to evaluate the effect of L-arginine supplementation on BP in MetS. Materials and Methods: In this randomized, double-blind, placebo-controlled trials, 60 patients with MetS were randomly divided into two groups: the ...

The probiotic Lactobacillus rhamnosus GR-1 has been documented to survive implantation onto the vaginal epithelium and interfere with urogenital pathogens. However, the molecular mechanisms involved are largely unknown. Here, we report for the first time the construction of dedicated knock-out mutants in L. rhamnosus GR-1 to enable the study of gene functions. In a search for genes responsible ...

Scope A high fructose and galactose intake show adverse metabolic effects in animal models humans, but it is yet unknown if addition of fermentable dietary fiber can mitigate such effects. This study investigate the intakes galactose, with/without added fructooligosaccharides (FOS), on factors, inflammation, gut integrity markers rats. Methods Results Rats (n = 6/group) receive different carboh...

Let C be a smooth curve of genus g. For each positive integer r the birational r-gonality sr(C) of C is the minimal integer t such that there is L ∈ Pic(C) with h(C,L) = r + 1. Fix an integer r ≥ 3. In this paper we prove the existence of an integer gr such that for every integer g ≥ gr there is a smooth curve C of genus g with sr+1(C)/(r + 1) > sr(C)/r, i.e. in the sequence of all birational g...

The aim of this study was to evaluate the involvement of nitric oxide (NO) system damage in the deleterious effects of high-fructose intake in rats. Fructose was administered as 10% solution in drinking water to twelve-week-old male Wistar rats for the period of 8 weeks. Blood pressure was measured by tail-cuff plethysmography. After sacrificing the rats at the end of the treatment, relative we...

The two genes lacZ1 and lacZ2 from Klebsiella pneumoniae 285, encoding β-galactosidase isoenzymes II and III (KpBGase-II and -III), were each cloned downstream of a T7 promoter for expression in Escherichia coli BL21(DE3), and the resulting recombinant enzymes were characterized in detail. The optimum temperature and pH value of KpBGase-II were 40 °C and 7.5, and those of KpBGase-III were 50 °C...