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background: during the resent years there has been interest in using bone marrow stem cells to treat liver cirrhosis. however, there is a potential concern for malignant transformation after stem cell therapy. the aim of this study was to evaluate the development of hepatocellular carcinoma (hcc) after autologous bone marrow stem cell transplantation for liver cirrhosis. methods: all the patien...

ex vivo expansion of human umbilical cord blood cells (hucbc) is explored by several investigators to enhance the repopulating potential of hucbc. the proliferation and expansion of human hematopoietic stem cells (hsc) in ex vivo culture was examined with the goal of generating a suitable clinical protocol for expanding hsc for patient transplantation. using primary human mesenchymal stem cells...

In the Abstract: ‘‘Further, we show that hiPSCs cultured with CCL2 can differentiate at a higher efficiency than culturing with just bFGF and we show CCL2 can be used in feeder-free conditions in the absence of LIF’’ should read ‘‘Further, we show that hiPSCs cultured withCCL2 can differentiate at a higher efficiency than culturing with just bFGF and we show CCL2 can be used in feeder-free cond...

there is a great concern about the effect of propoxur, as one of the more common n-methyl carbamate pesticides, on human health due to its extensive use in agricultural and non-agricultural applications. caco-2 cells became resistant to propoxur, and the resistance was confirmed through mtt assay. then the cell membrane integrity and p-glycoprotein expression were measured by ldh assay and west...

the brain and spinal cord have a limited capacity for self-repair under damaged conditions. one of the best options to overcome these limitations involves the use of phytochemicals as potential therapeutic agents. in this study, we have aimed to investigate the effects of di-(2-ethylhexyl) phthalate (dehp) on hippocampus-derived neural stem cells (nscs) proliferation to search phytochemical can...

background: multiple sclerosis (ms) is a t cell mediated autoimmune disease with unknown etiology. appropriate ms therapeutic strategies need thorough understanding of both disease etiology and pathogenesis mechanisms. ligation of tlr-2 and tlr-4 stimulates the production of several cytokines leading to cns autoimmunity and neurodegenerative diseases. objective: to find a relationship between m...