There is a need for new analytical approaches to better characterize the nature of the concentration-dependent, reversible self-association (RSA) of monoclonal antibodies (mAbs) directly, and with high resolution, when these proteins are formulated as highly concentrated solutions. In the work reported here, hydrogen exchange mass spectrometry (HX-MS) was used to define the concentration-depend...

delayed neuronal death after seizure attack may be mediated by the induction of apoptosis-pathway. caspase-3, a mammalian cysteine protease, promotes apoptosis after some neurological disorders. neuron regeneration peptides (nrps) are small synthetic peptides that stimulate neural proliferation, migration, and differentiation with no apparent toxicity and high target specificity in cns. in the ...

BACKGROUND AND PURPOSE In 2006, the American Heart Association recommended that carotid revascularization generally occurs within 2 weeks of stroke based on data from 2 trials of carotid endarterectomy (CEA). We aimed to determine whether the time between stroke and CEA or carotid artery stenting (CAS) has decreased and whether the proportion of procedures occurring within 14 days has increased...

Meat tenderness is one of the key factors determining consumer satisfaction and food quality. Freeze drying a critical aspect preservation. Foods produced this way can be stored for an exceedingly long time, but they are characterized by being very hard in texture requiring rehydration before use. This study presents investigation focusing on finding preparation parameters freeze-dried meat tha...

Ice-templating techniques, including freeze-drying and freeze casting, are extremely versatile and can be used with a variety of materials systems. The process relies on the freezing of a water based solution. During freezing, ice nucleates within the solution and concentrates the solute in the regions between the growing crystals. Once the ice is removed via sublimation, the solute remains in ...

Abstract Climate attributes such as precipitation, extreme temperature, and freeze-thaw cycles along with traffic loads cause pavement distresses. The maintenance need for pavements is decided based on the condition rating International Roughness Index (IRI). Generally, an IRI less than 2.68 m/km acceptable, a greater considered unacceptable classified “very poor” of pavement. It imperative to ...

A freezing-point apparatus, which measures osmotic pressure by determining freezingpoint depression, was modified by incorporating a slowly rotating circular tray with space for 30 sample vials, and a sample pick-up device. The instrument is designed to automatically pick up a cuvet containing a 2-mi. specimen of serum, urine, spinal fluid, or any biologic fluid, and to cool, supercool, freeze,...

Abstract The Covid-19 pandemic requires a continuous evaluation of whether current policies and measures taken are sufficient to protect vulnerable populations. One quantitative indicator policy effectiveness severity is the case fatality ratio, which relies on lagged number infections relative deaths. appropriate length time lag be used, however, heavily debated. In this article, I contribute ...

In Greek instructive texts, the production of clear and precise instructions is achieved by both prosodic modelling (Alexandris, Fotinea & Efthimiou, 2005) and morphosyntactic strategies (Alexandris, 2005). In the set of experiments performed in the present study, we attempt to determine whether prosodic modelling or whether morphosyntactic strategies, namely word order, constitutes the most cr...