A mild and efficient o- and p-nitrobenzyl cleavage protocol was developed. o- and p-Nitrobenzyl groups were easily removed from a variety of substrates using 20% aqueous NaOH in methanol at 75 °C, presumably via oxidation at the benzylic position by oxygen dissolved in the solution. These easily introducible and removable nitrobenzyl groups can serve as valuable protecting groups for the synthe...

Egeberg A, Bruun LE, Mallbris L, Gislason GH, Skov L, Wu JJ, Hansen PR. Family history predicts major adverse cardiovascular events (MACE) in young adults with psoriasis. J Am Acad Dermatol. 2016 Aug;75(2):340-6. • Danish citizens aged 18 years or older from January 1, 1997, to December 31, 2011 • Population of 5,536,422 • If + family history of MACE, there is increased incidence rate ratios of...

A new nanocluster of atomic precision, Au44(SC2H4Ph)32, is obtained by an oxidation-decomposition-recombination (ODR) process from Au25(SC2H4Ph)18 under mild conditions with high yield (75%). Among the investigated gold nanoclusters, Au44(SC2H4Ph)32 exhibits the highest catalytic activity for the reduction of 4-nitrophenol, especially at low temperature, indicating that the catalytic properties...

A 75-year-old man with a 25-year history of type 2 diabetes presents for long-term treatment options. His estimated glomerular filtration rate is 16 mL per minute per 1.73 m(2) of body-surface area. His history is remarkable for ischemic coronary artery disease, congestive heart failure, peripheral artery disease, mild dementia, and colon cancer. He has been admitted to the hospital 4 times in ...

The potential of early interventions for dementia has increased interest in cognitive impairments less severe than dementia. However, predictors of the trajectory from intact cognition to dementia have not yet been clearly identified. The purpose of this study was to determine whether known risk factors for dementia increased the risk of mild cognitive impairments or progression from mild cogni...

Subclinical thyroid dysfunction (STD) represents a condition of slight thyroid hormone excess or deficiency, which may be associated with important adverse effects. This review will focus on the natural history, diagnosis and management of subclinical thyroid dysfunction. Since STD is only detected as a thyroid stimulating hormone (TSH) abnormality, it is essential to exclude transient causes o...

Type 2N Von Willebrand's disease (2N VWD) is a rare, recessively inherited bleeding disorder, comprising 1-2% of all VWD patients, usually manifesting as a mild bleeding diathesis. Treatment includes desmopressin (DDAVP) or intermediate purity plasma-derived FVIII concentrates containing residual VWF. We present a case of a 75-year-old gentleman, incidentally diagnosed with type 2N VWD in 2002 ...

A 75-year-old woman was admitted for severe retrosternal chest pain. Her past medical history revealed mild diabetes mellitus and bifasciscular block (left anterior hemiblock [LAHI and incomplete right bundle-branch block [RBBB]). The electrocardiogram was compatible with a subendocardial (non-Q wave) inferior and anterolateral AMI. This was characterized by new ST-segment depression and T-wave...

Why beat about the bush? An operationally simple and mild reaction based on the direct fixation of (11)CO(2) with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) has been developed for the synthesis of (11)C-labeled carbamates at 75 degrees C within 10 minutes in radiochemical yields above 70% (see scheme). This strategy should be immediately useful for the construction of new radiotracers for positro...