myeloid sarcoma or granulocytic sarcoma (gs) is a rare disease with poor prognosis. it is characterized by the occurrence of tumor masses at an extra-medullary tissue. it is composed of myeloblastic cells and usually occurs in association with acute myeloid leukemia. because of its nonspecific clinical and radiologic findings, its diagnosis might be challenging. it might be more commonly found ...

Myeloid sarcoma in acute myeloid leukemia has been clearly defined by the World Health Organization but studies regarding the prevalence and the prognostic impact of extramedullary acute myeloid leukemia have not been conducted. We performed (18)Fluoro-deoxy-Glucose Positron Emission Tomography/Computed Tomography scans in 10 patients with de novo and relapsed acute myeloid leukemia and histolo...

Mediastinal Myeloid Sarcoma is a rare entity. Here we present case of 28-year-old gentleman, who first presented with mediastinal mass and was clinically considered lymphoblastic lymphoma. He diagnosed initially as having T lymphoma on trucut biopsy. After one month patient Acute myeloid leukemia peripheral smear bone marrow examination confirmed the help flow cytometry. The biopsy slides from ...

Nitric oxide (NO) is a molecule required for many physiological functions, produced from L-arginine by NO synthases (NOS). It is a free radical, producing many reactive intermediates that account for its bioactivity. Sustained induction of the inducible form of NOS (iNOS) in chronic inflammation may be mutagenic, through NO-mediated DNA damage or hindrance to DNA repair, and thus potentially ca...

Acute myeloid leukemia is characterized by a malignant proliferation of hematopoietic progenitor cells of the myeloid lineage. The lack of differentiation of precursor cells causes their inability to function normally and the disruption of normal hematopoiesis. This review provides a brief overview of the most important pharmacological strategies that impact on acute myeloid leukemia cure rates...

We examined the gene expression profiles of two independent cohorts of patients with acute myeloid leukemia [n=247 and n=214 (younger than or equal to 60 years)] to study the applicability of gene expression profiling as a single assay in prediction of acute myeloid leukemia-specific molecular subtypes. The favorable cytogenetic acute myeloid leukemia subtypes, i.e., acute myeloid leukemia with...

We conducted a case-control study to investigate the role of ABCB1 C3435T (rs1045642) and C1236T (rs1128503) gene polymorphisms in the susceptibility to acute myeloid leukemia. The polymerase chain reaction (PCR) coupled with restriction fragment length polymorphism (RFLP) method was carried out to genotyping ABCB1 C3435T and C1236T gene polymorphism. Statistical analysis was conducted using th...

The PI3K/AKT and mTOR signaling pathways are activated in acute myeloid leukemia, including in the more immature leukemic populations. Constitutive PI3K activation is detectable in 50% of acute myeloid leukemia samples whereas mTORC1 is activated in all cases of this disease. In leukemic cells, the PI3K activity relates to the expression of the p110delta isoform of class IA PI3K. Constitutive P...

The relation between diet, lifestyle, and acute myeloid leukemia was assessed in a US cohort of 491,163 persons from the NIH-AARP Diet and Health Study (1995-2003). A total of 338 incident cases of acute myeloid leukemia were ascertained. Multivariate Cox models were utilized to estimate hazard ratios and 95% confidence intervals. Compared with those for never smokers, hazard ratios were 1.29 (...