The effects of acute thrombocytopenia, produced by platelet antiserum (PAS), on both megakaryocyte colony-forming cells (Meg-CFC) and granulocyte-macrophage colony-forming cells (GM-CFC) were studied. During the 1-hr to 14-day period following acute thrombocytopenia (platelet counts < 5% of normal), bone marrow and splenic cells of C57BL/6J mice were obtained and cultured for 7 days in 0.3% aga...

conclusions sever thrombocytopenia and bleeding may be the presentation of brucellosis. case presentation we report on an eight-year-old boy who presented epistaxis and gum bleeding. the physical examination revealed petechiae, purpura, ecchymosis, and cervical while inguinal lymphadenopathy and splenomegaly were noted. brucella agglutinin titer was positive. after five days of specific therapy...

ABBREVIATIONS IN THIS CHAPTER ACS Acute coronary syndrome BMS Bare metal stent CABG Coronary artery bypass grafting DAPT Dual antiplatelet therapy DES Drug-eluting stent GPI Glycoprotein IIb/IIIa inhibitor HIT Heparin-induced thrombocytopenia NSTE ACS Non–ST-segment elevation acute coronary syndrome PCI Percutaneous coronary intervention STEMI ST-segment elevation myocardial infarction UA Unsta...

BACKGROUND Cytopenia caused by ineffective hematopoiesis and monocyte overproduction coexist in CMML, providing grounds for discussion to supporters of a dysplastic versus a proliferative identity for CMML. Follow-up information from a large series of patients may contribute to clarifying the position of this infrequent disease. METHODS We analyzed data from 77 patients followed in five insti...

Aim of the study: Malaria is major health problem in the tropics with significant high mortality and morbidity.Malaria is usually associated with reduced blood cell counts & mild to moderate thrombocytopenia which is a common association of malaria. The cause of thrombocytopenia is poorly understood, but the immune-mediated lysis, sequestration in the spleen and dyspoietic processes in the marr...

Background: Thrombocytopenia is commonly encountered in a wide range of haematological and non-haematological disorders. Bone marrow examination plays a major role in diagnosis. Aims: The aim of our study was to analyse the etiology and to study megakaryocytic series in different cases of thrombocytopenia, irrespective of age or sex. Methods: This prospective bone marrow aspiration study was do...

Acute myocardial infarction (AMI) in patients with immune thrombocytopenic purpura (ITP) is rare. We describe a case of AMI in patient with ITP. An 81-year-old woman presented with acute inferoposterior MI with low platelet count on admission (34,000/µl). Coronary angiography revealed significant mid right coronary artery (RCA) stenosis with thrombus, subsequently underwent successful percutane...

OBJECTIVE To evaluate potential risk factors, presenting symptoms, management, and outcomes of intracranial haemorrhage in Chinese children with immune thrombocytopenia managed in a regional hospital. DESIGN Retrospective case series. SETTING A regional hospital in Hong Kong. PATIENTS All paediatric patients with immune thrombocytopenia complicated by intracranial haemorrhage in the perio...

Acute thrombocytopenia is a recognized complication of treatment with GPIIb/IIIa inhibitors whose cause is not yet known. We studied 9 patients who developed severe thrombocytopenia (platelets less than 25 x 10(9)/L) within several hours of treatment with the GPIIb/IIIa inhibitors tirofiban (4 patients) and eptifibatide (5 patients). In each patient, acute-phase serum contained a high titer (ra...