OBJECTIVE Adenosine deaminase acts on adenosine and deoxyadenosine metabolism and modulates the immune response. The adenosine deaminase G22A polymorphism (20q.11.33) influences the level of adenosine deaminase enzyme expression, which seems to play a key role in maintaining pregnancy. The adenosine deaminase 2 phenotype has been associated with a protective effect against recurrent spontaneous...

The 'omnipresence' of adenosine in all nervous system cells (neurons and glia) together with the intensive release of adenosine following insults, makes adenosine as a sort of 'maestro' of synapses leading to the homeostatic coordination of brain function. Besides direct actions of adenosine on the neurosecretory mechanisms, where adenosine operates to tune neurotransmitter release, receptor-re...

Double-stranded RNA (dsRNA)-specific adenosine deaminase converts adenosine to inosine in dsRNA. The protein has been purified from calf thymus, and here we describe the cloning of cDNAs encoding both the human and rat proteins as well as a partial bovine clone. The human and rat clones are very similar at the amino acid level except at their N termini and contain three dsRNA binding motifs, a ...

Harrington, Elizabeth O., Julie Newton, Nicole Morin, and Sharon Rounds. Barrier dysfunction and RhoA activation are blunted by homocysteine and adenosine in pulmonary endothelium. Am J Physiol Lung Cell Mol Physiol 287: L1091–L1097, 2004. First published July 30, 2004; doi:10.1152/ajplung.00421.2003.—RhoA GTPases modulate endothelial permeability. We have previously shown that adenosine and ho...

It is now generally accepted that adenosine is capable of regulating a wide range of physiological functions. Nowhere is the diversity of this action better illustrated than in the kidney. When adenosine binds to plasma membrane receptors on a variety of cell types in the kidney, it stimulates functional responses that span the entire spectrum of renal physiology, including alterations in hemod...

the complexes of mn(oac)3 and/or mn(acac)3 with nucleic bases and nucleosides (adenine, guanine, xanthine, adenosine and guanosine) have been synthesized in nonaqueous solution. polarographic and spectroscopic (ir and visible) methods have been used to establish the active site(s) on the imidazole and pyrimidine rings in the nucleic bases and nucleosides for the interaction with the mn(iii) com...

Adenosine produced a severalfold amplification of luteinizing hormone (LH)-stimulated cAMP accumulation and progesterone secretion in rat luteal cells, but showed no similar effect on LH-stimulated cAMP accumulation and androgen secretion in Leydig cells. In the absence of LH, adenosine produced a small but significant stimulation of cAMP accumulation and steroid secretion in both luteal and Le...

Aim. To assess external respiration (ER) and its relationship with the activity of enzymes involved in purine metabolism patients acute chronic forms pulmonary tuberculosis (TB). Materials methods. In TB, we assessed adenosine deaminase (ADA)-1, 2 blood serum (eADA), mononuclear cells, neutrophils, concentration ecto-5’-nucleotidase (eNT5E) serum, level CD26 (dipeptidyl peptidase-4, DPPIV) prod...

Immediate decreases of the concentrations of glycogen and phosphocreatine are found in continuously working muscles, and many seconds later decreases of the adenosine triphosphate are found also, The hydrolysis of the adenosine triphosphate, which involves the liberation of 2 moles of phosphate, may be detected in 40 seconds and reaches its maximumin 1 or 2 minutes in muscles working at the rat...

We have observed that the elevated plasma adenosine levels are associated with hyperuricemia in nonpreeclamptic twin pregnancies. In animal models, extracellular adenosine is taken up by cells to form adenine nucleotides or is degraded to other purine metabolites such as hypoxanthine, which is further metabolized to xanthine and uric acid. In this study, we measured plasma hypoxanthine levels t...