chronic obstructive pulmonary disease (copd) has been defined by the global initiative for chronic obstructive lung disease (gold), as a disease state characterized by airflow limitation which is not fully reversible. copd consists of emphysema which is the destruction and inflammation of the lung alveoli. adenosine deaminase (ada, e.c.3.5.4.4) converts adenosine to inosine. there are two isoen...

background: significant elevation of cardiac biomarkers after percutaneous coronary intervention (pci) is associated with increased mortality. however, clinical importance of lesser degrees of cardiac enzyme elevation has not been well understood. multiple factors might have an etiologic role, and the incidence of myonecrosis has not changed dramatically despite pharmacological and technologica...

background: we report the analgesic efficacy of lumbar epidural adenosine injection in reducing the chronic neuropathic pain in a patient with primitive neuroectodermal tumor. report of the case: in this case report a 13-year-old male with primary neuroectodermal tumor (pnet) was administered in epidural space with adenosine to reduce his pain. the patient received 10ml of 0.25% ropivacaine and...

normal 0 false false false en-us x-none ar-sa background: in some studies, the level of adenosine deaminase ( ada) in sputum and effusion liquids was used for the diagnosis of tuberculosis (tb). but it is not always possible to access these materials. the goal of this study is to assess the diagnostic value of serum ada levels in pulmonary tb patients. materials and methods: in this study, 40 s...

Background: We report the analgesic efficacy of lumbar epidural adenosine injection in reducing the chronic neuropathic pain in a patient with primitive neuroectodermal tumor. Report of the Case: In this case report a 13-year-old male with primary neuroectodermal tumor (PNET) was administered in epidural space with adenosine to reduce his pain. The patient received 10ml of 0.25% ropivacaine ...

Although the purine adenosine acts as an extracellular neuromodulator in the mammalian CNS in both normal and pathological conditions and regulates sleep, the regulation of extracellular adenosine in the day and night is incompletely understood. To determine how extracellular adenosine is regulated, rabbit neural retinas were maintained by superfusion at different times of the regular light/dar...

Tuberculosis (TB) remains one of the health problems in Nigeria and worldwide. Adenosine Deaminase acts proliferation differentiation lymphocyte, especially T lymphocyte. It also maturation monocytes transforming them to macrophage. is a significant indicator active cellular immunity. has been proposed be useful surrogate marker for TB because it can detected body fluids such as pleural, perica...

In this study the uptake and metabolism of adenosine by mitochondria has been investigated. Incubation of CEM cells mitochondria preparation with [3H] -adenosine showed substantial uptake and metabolism of adenosine. Adenosine was both anabolized to AMP, ADP and ATP, and also catabolized to inosine. The highest concentration of metabolites in extracted mitochondria was due to AMP. The mito...