Parkinson disease is one of the neurodegenetive disease with a prevalence of about 1% in people older than 65.from a pathological point of view,degeneration of neuromelanin cells in pars compacta of substantia nigra has been established.the reason of degeneration is unknouwn.increase in iron concentration in substantia of parkinson,s patients has been established.the  increase of iron in this p...

OBJECTIVE To evaluate the socio-demographic and clinical feature of patients with Parkinson`s disease, their health-related quality of life (HRQoL), and the relationship between these. METHODS This cross-sectional study was conducted in Istanbul University Cerrahpasa Medical Faculty Hospital, and Ministry of Health, Taksim and Haseki Education and Research Hospitals in Istanbul, Turkey. The s...

Parkinson disease (PD) is a degenerative neurological disorder that affects 0.5- 1% of old people in western countries. It primarily affects mobility function, and associated with increasing disability over time. People with PD express bradykinesia, rigidity, tremor, progressive postural instability and muscle weakness as symptoms of PD. Various exercise programs, including resistance or aerobi...

BACKGROUND Pedunculopontine nucleus (PPN) stimulation is a novel therapy for Parkinson disease. However, controversies remain regarding the clinical application of this new therapy, including patient selection, electrode positioning, and how best to assess outcomes. OBJECTIVE To clarify the clinical application of PPN stimulation in Parkinson disease. METHODS Five consecutive patients with ...

BACKGROUND The detection of hyperechogenicity of the substantia nigra using trans cranial sonography can be predictive of the diagnosis of Parkinson Disease. AIM To report an experience with transcranial sonography for the diagnosis of Parkinson disease. Material ana METHODS One hundred sixteen patients with movement disorders were subjected to a transcranial sonography to detect the presen...

P73 is a member of the p53 transcription factors family with a prominent role in neurobiology, affecting brain development as well as controlling neuronal survival. Accordingly, p73 has been identified as key player in many age-related neurodegenerative diseases, such as Alzheimer's disease, neuroAIDS and Niemann-Pick type C disease. Here we investigate possible correlations of p73 with Parkins...

OBJECTIVE The retrieval deficit hypothesis states that the lack of deficit in recognition often observed in patients with Parkinson's disease is because of the low retrieval requirements of the task, given that these patients have retrieval and not encoding deficits. To test this hypothesis we investigated recognition memory by familiarity in Parkinson's patients and in patients with Lewy Bodie...