Recently we have developed novel oxotriazinoindole inhibitors (OTIs) of aldose reductase (ALR2), characterized by high efficacy and selectivity. Herein describe OTI derivatives design which is based on implementation additional intermolecular interactions within an unoccupied pocket the ALR2 enzyme. Four derivatives, OTI-(7–10), previously N-benzyl(oxotriazinoindole) inhibitor OTI-6 were synthe...

As a versatile and valuable intermediate, furfuryl alcohol (FOL) is widely utilized in manufacturing vitamin C, perfume, fruit acid, lubricant, lysine, plasticizer, dispersing agent, resin, fuel additive, biofuel. This study aimed at the establishment of cascade catalysis biomass to FOL via hybrid approach deep eutectic solvent medium. The corn stover (75 g/L) with solid acid AT-Sn-WLS (1.2 wt%...

Flavoproteins have long been recognized as hydrogen and electron carriers between pyridine nucleotides and cytochromes. Cytochrome reductases the oxidation-reduction mechanisms of which have been extensively studied (1) have contained metals, as have other flavin enzymes with cytochrome reductase activity, such as xanthine oxidase (a), liver aldehyde oxidase (3), and Neurospora (4) and Pseudomo...

Bacterial light production involves enzymes-luciferase, fatty acid reductase, and flavin reductase-and substrates-reduced flavin mononucleotide and long-chain fatty aldehyde-that are specific to bioluminescence in bacteria. The bacterial genes coding for these enzymes, luxA and luxB for the subunits of luciferase; luxC, luxD, and luxE for the components of the fatty acid reductase; and luxG for...

Reductive metabolism of carcinogenic 1-nitropyrene by rat liver microsomes and reconstituted cytochrome P-450 systems was investigated. Under the nitrogen atmosphere, 1-aminopyrene was the only detected metabolite of 1-nitropyrene. The reductase activity in liver 105,000 X g supernatant fraction was ascribed to DT-diaphorase, aldehyde oxidase, and other unknown enzyme(s) from the results of cof...

Flavoproteins have long been recognized as hydrogen and electron carriers between pyridine nucleotides and cytochromes. Cytochrome reductases the oxidation-reduction mechanisms of which have been extensively studied (1) have contained metals, as have other flavin enzymes with cytochrome reductase activity, such as xanthine oxidase (a), liver aldehyde oxidase (3), and Neurospora (4) and Pseudomo...

Human liver contains at least two isoenzymes (DD2 and DD4) of 3α-hydroxysteroid}dihydrodiol dehydrogenase. The NADP(H)-linked oxidoreductase activities of DD4 were activated more than 4-fold by sulphobromophthalein at concentrations above 20 μM and under physiological pH conditions. Sulphobromophthalein did not stimulate the activities of DD2 and human liver aldehyde reductase, which are functi...