background and aims: portulaca oleracea (purslane) herb has renewed an interest in medicinal plants because its aerial parts usage generally does not elicit any side effects. in the present study, we aimed to evaluate the anti-diabetic effect of hydro-ethanolic extract of p. oleracea seeds in alloxan- induced diabetic rats. materials and methods: in the test group, diabetic rats received hydroe...

The effect of alloxan diabetes on the activity of monoamine oxidase was studied in three regions of the rat brain at various time intervals after the onset of diabetes. It was observed that monoamine oxidase activity was decreased at early time intervals after diabetes, followed by a recovery in all three regions of the brain. A reversal of the effect was observed with insulin administration to...

THERE have been relatively few studies of the carbohydrate metabolism of the retina of the alloxan-diabetic animal and not all have been in agreement. Illing and Gray (1951) described an impairment of glucose utilization in the retina of diabetic rabbits, but these results were not confirmed by Kornblueth, Yardeni-Yaron, and Wertheimer (1953). DeRoetth and Pei (1960), using manometric technique...

BACKGROUND Many synthesized drugs with clinical severe side effects have been used for diabetic nephropathy (DN) treatment. Therefore, it is urgent and necessary to identify natural and safe agents to remedy DN. Timosaponin B-II (TB-II), a major steroidal saponin constituent in Anemarrhena asphodeloides Bunge, exhibits various activities, including anti-inflammatory and hypoglycemic functions. ...

BACKGROUND Ninety percent of cases of diabetes are of the slowly evolving non-insulin-dependent type, or Type 2 diabetes. Lack of exercise is regarded as one of the main causes of this disorder. In this study we analyzed the effects of physical exercise on glucose homeostasis in adult rats with type 2 diabetes induced by a neonatal injection of alloxan. METHODS Female Wistar rats aged 6 days ...

The effect of alloxan diabetes on mobilization of the liver glycogen was followed in male rats given one injection of alloxan (200mg/kg). The serum glucose showed a typical triphasic curve, reaching sustained hyperglycemia 24hr after injection. The insulin levels of serum and pancreatic tissue extract remained within normal limits for the first 24hr. The marked decrease in insulin levels from b...

Mung bean was reported as a potential antidiabetic agent while fermented food has been proposed as one of the major contributors that can reduce the risk of diabetes in Asian populations. In this study, we have compared the normoglycemic effect, glucose-induced hyperglycemic effect, and alloxan-induced hyperglycemic effect of fermented and nonfermented mung bean extracts. Our results showed tha...

to 28 mM glucose. Concomitantly the SOD-specific activity (units of enzyme activity per milligram immunoreactive SOD) decreased 50% in alloxan-exposed islets. When islets were protected from alloxan toxicity by including 28 mM glucose with alloxan, the insulin secretory response and SOD specific activity remained identical to controls. Thus, SOD specific activity correlates with maintenance of ...

Aqueous and ethanolic extract of Osbeckia nepalensis Hook was evaluated for the antihyperglycemic activity in alloxan induced diabetic rats. Hyperglycemic was confirmed to Albino rats (150200 g) by treated with alloxan upto 320.6 ± 3.59 at 1 hr, 445.6 ± 4.23 at 5 days from non treated rats of 316 ± 3.56± mg/ dL. A significant hypoglycemic activity of aqueous and ethanolic extract was confirmed ...

1. The activities of hydroxymethylglutaryl-CoA synthase and lyase in rat liver were found to be two- to 15-fold greater than those reported by other authors under similar conditions. 2. When expressed on the basis of body weight, no appreciable differences were found between the activities of hydroxymethylglutaryl-CoA synthase in whole homogenates of livers from normal and starved rats. The syn...