A series of novel O-doped polycyclic aromatic hydrocarbons, bearing a different number electron-donating alkoxy substituents, has been prepared using copper-promoted anaerobic protocol for the cyclisation highly electron rich peri-xanthenoxanthene molecular modules. The effect and position substituents on optoelectronic properties thus investigated, unveiling p-type semiconducting properties. A...

(pyrazol-3-yl)pyridmium group at the C-3' position as a combination of the pyridine moiety of ceftazidime2) and the pyrazole moiety of cefoselis3) to attain a synergic effect in activity. As we expected, those compoundsexhibited wellbalanced and broad spectrum of activity against Grampositive and Gram-negative bacteria. Of them, 7-[(Z)-2-(2aminol ,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-3[(3...

A synthesis of tetrasubstituted pyrazoles containing two, three or four pyridinyl substituents is described. Hence, the reaction of 1,3-dipyridinyl-1,3-propanediones with 2-hydrazinopyridine or phenylhydrazine, respectively, affords the corresponding 1,3,5-trisubstituted pyrazoles. Iodination at the 4-position of the pyrazole nucleus by treatment with I2/HIO3 gives the appropriate 4-iodopyrazol...

The Milstein's reported discovery of hydrogenation thioesters directly toward thiols and alcohols catalyzed by a Ru-acridine complex has been studied here DFT calculations to know the origin different performance depending on nature substituents. Unveiling reaction mechanism leads deeper understanding steric electronic properties limiting step reaction. Steric maps Conceptual have tools rationa...

The relationship between chemical structure and the concentration at which self-association occurs in water or in 0.15 M Na+ ion was examined for more than 50 bile salts and bile salt analogues varying in substituents on the steroid nucleus or in the structure of the side chain. Nuclear substituents varied in type (alpha- or beta-hydroxy, or oxo group) and number (1, 2, or 3); side chain struct...

Comparative study of electrochemical redox behaviour of five different nitroxyl radicals leads to the direct correlation between one-electron redox potentials and group electronegativity of the beta-substituent on the ring. Beta-substituents with an electron-donating effect caused a negative shift in the one-electron oxidation and one-electron reduction potentials of the nitroxyl radicals. In a...

1,6-Enynes with electron-donating substituents at the alkyne undergo gold(I)-catalysed single cleavage skeletal rearrangement, whereas substrates with electron-withdrawing substituents evolve selectively to double cleavage rearrangement. Theoretical calculations provide a qualitative rationale for these effects, and suggest that bicyclo[3.2.0]hept-5-enes are involved as intermediates. We provid...