Insulin resistance and obesity are associated in children as they are in adults. However, although insulin resistance seems to oppose further weight gain in adults, opposite results have been found in children. To investigate the relationship between childhood obesity, insulin resistance, and long-term weight gain, we selected 215 obese Caucasian children (120 males and 95 females) aged 10.5 (+...

Objectives: Insulin resistance and dyslipidemia are common comorbidities of polycystic ovary syndrome. We aim to evaluate the association between triglycerides/high-density lipoprotein cholesterol ratio, insulin resistance, serum androgen levels in patients with Methods: enrolled a total 40 syndrome 20 healthy control subjects this cross-sectional study. The were divided into two subgroups obes...

BACKGROUND Insulin resistance is the primary metabolic disorder associated with obesity; yet little is known about its role as a determinant of the metabolic syndrome in obese children. The aim of this study is to assess the association between the degree of insulin resistance and the different components of the metabolic syndrome among obese children and adolescents. METHODS An analytical, c...

adenosine deaminase (ada) is an important regulator of insulin action. the single nucleotide polymorphism (snp) g22a in the ada gene decreases enzymatic activity of ada. the aim of this study was to investigate the relationship between the snp g22a and blood glycemic control, insulin resistance, and obesity of gestational diabetes mellitus (gdm) patients in an iranian population. snp g22a was d...

Plasma glucose, insulin, and C-peptide concentrations were determined in response to graded infusions of glucose, and insulin secretion rates were calculated over each sampling period. Measurements were also made of insulin clearance, resistance to insulin-mediated glucose, uptake, and the plasma glucose, insulin, and C-peptide concentrations at hourly intervals from 8:00 AM to 4:00 PM in respo...

Hyperinsulinaemia is the earliest subclinical metabolic abnormality, which precedes insulin resistance in obese children. An investigation was conducted on the potential predictors of fasting insulin and insulin resistance among overweight/obese adolescents in a developing Asian country. A total of 173 overweight/obese (BMI > 85th percentile) multi-ethnic Malaysian adolescents aged 13 were recr...

OBJECTIVE Increased visceral adiposity has been closely linked to insulin resistance, endothelial dysfunction, and cardiometabolic disease in obesity, but pathophysiological mechanisms are poorly understood. We sought to investigate mechanisms of vascular insulin resistance by characterizing depot-specific insulin responses and gain evidence that altered functionality of transcription factor fo...

BACKGROUND Insulin resistance has an important role in pathophysiology of polycystic ovarian syndrome (PCOS). Yet there are certain controversies regarding the presence of insulin resistance in non-obese patients. OBJECTIVE The aim was to compare the insulin resistance and various endocrine and metabolic abnormalities in obese and non-obese PCOS women. MATERIALS AND METHODS In this cross-se...