Considerable amounts of IRS are secreted after secretin injection in human pancreatic juice collected during endoscopic retrograde cholangiopancreatography. The mean IRS levels in the pancreatic juice of non-diabetic patients were 79 +/- 10 (SE) pg/ml. The IRS levels in NIDDM were considerably higher, the mean value being 1635 +/- 313 (SE) pg/ml. The mean IRS level in IDDM were 312 +/- 151 (SE)...

Intelligent reflecting surface (IRS) is a rapidly emerging paradigm to enable non-line-of-sight (NLoS) wireless transmission. In this paper, we focus on IRS-aided radar estimation performance of moving hidden or NLoS target. Unlike prior works that employ single IRS, investigate problem using multiple IRS platforms and assess the by deriving associated Cramér-Rao lower bound (CRLB). We then des...

The mammalian target of rapamycin (mTOR) integrates signals from nutrients and insulin via two distinct complexes, mTORC1 and mTORC2. Disruption of mTORC2 impairs the insulin-induced activation of Akt, an mTORC2 substrate. Here, we found that mTORC2 can also regulate insulin signaling at the level of insulin receptor substrate-1 (IRS-1). Despite phosphorylation at the mTORC1-mediated serine sit...

IRS-III is the first WSMO compliant system for supporting the Semantic Web Services technologies and it is based on the IRS-II [3]. This paper presents how we integrated the OWL-S [5] service description ontology to IRS-III. We describe how the underlying model of IRS-III supports OWL-S.

OBJECTIVE Insulin receptor substrate-2 (IRS-2) plays an essential role in pancreatic islet β-cells by promoting growth and survival. IRS-2 turnover is rapid in primary β-cells, but its expression is highly regulated at the transcriptional level, especially by glucose. The aim was to investigate the molecular mechanism on how glucose regulates IRS-2 gene expression in β-cells. RESEARCH DESIGN ...

Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF), the critical molecule in tumor angiogenesis, is regulated by different stimuli, such as hypoxia and oncogenes, and also by growth factors. Previously we have shown that in AsPC-1 pancreatic adenocarcinoma cells, insulin-like growth factor receptor (IGF-IR) regulates VPF/VEGF expression. Insulin receptor substrate-1 and ...

Imaging polarimetry of the 850 km continuum emission in the NGC 7538 region, obtained with the SCUBA Polarimeter, is presented. The polarization map is interpreted in terms of thermal radiation by magnetically aligned dust grains. Two prominent cores associated with IRS 1 and IRS 11, IRS 1(SMM), and IRS 11(SMM), are found in the surface brightness map. Although these cores look similar in surfa...

Context. IRAS 20343+4129 was suggested to harbor one of the most massive and embedded stars in the Cygnus OB2 association, IRS 1, which seemed to be associated with a north-south molecular outflow. However, the dust emission peaks do not coincide with the position of IRS 1, but lie on either side of another massive Young Stellar Object (YSO), IRS 3, which is associated with centimeter emission....