objective: to assess the level of awareness on breast cancer among women of reproductive age. materials and methods: a cross-sectional descriptive study was conducted in opd of dhaka medical college hospital among the 175 respondents by face to face interview using pretested semi structured questionnaire. results: one forth (23%) aged 21-25 years, mostly muslim (86.3%), housewives (72.57%), had...

Two set of 2-aryl-5,6-dihydropyrrolo[2,1-a] isoquinolines were designed and synthesized to evaluate their biological activities as topoisomerase inhibitors. Cytotoxic activity of the synthesized compounds 4a-e and 7a-d was assessed against several human cancer cell lines, including MCF-7 (breast cancer cell), HepG2 (liver hepatocellular cells), A549 (adenocarcinomic human alveolar basal epithel...

Geraniol is an acyclic monoterpenoid compound, which exists widely in aromatic plants. has antibacterial and anti-inflammatory effects. Recently, it been found that geraniol a strong effect on improving immune function anti-tumor. Many experimental evidences support good the treatment or prevention of different types tumors, such as breast cancer, lung liver pancreatic colon prostate etc. also ...

abstract boswellia has been widely used in traditional medicine for the treatment of different diseases such as cancer in iran. the aim of this study was to evaluate the effect of the gum methanol extract of boswellia thurifera on the viability and p53 gene expression of cultured breast cancer cells. the gum methanol extract was obtained in various concentrations using the maceration method. no...

Background: Carnosine is a dipeptide molecule (?-alanyl-l-histidine) with anti-inflammatory, antioxidant, anti-glycation, and chelating properties. It used in exercise physiology as food supplement to increase performance; however, vitro evidence suggests that carnosine may exhibit anti-cancer Methods: In this study, we investigated the effect of on breast, ovarian, colon, leukemic cancer cell ...

Two set of 2-aryl-5,6-dihydropyrrolo[2,1-a] isoquinolines were designed and synthesized to evaluate their biological activities as topoisomerase inhibitors. Cytotoxic activity of the synthesized compounds 4a-e and 7a-d was assessed against several human cancer cell lines, including MCF-7 (breast cancer cell), HepG2 (liver hepatocellular cells), A549 (adenocarcinomic human alveolar basal epithel...

Although drugs like doxorubicin, tamoxifen and herceptin are widely employed in breast cancer therapy, they are known to cause side effects such as cardio-toxicity, endometrial cancer and congestive heart failure respectively. Treatment of triple negative breast cancer (TNBC) is still challenging for clinicians and researchers, as most of the patients do not respond to traditional chemotherapeu...

PURPOSE Breast cancer stem cells (CSCs) are responsible for the initiation, recurrence, and metastasis of breast cancer. Sufficient evidence has established that breast cancer cells can spontaneously turn into breast CSCs. Thus, it is essential to simultaneously target breast CSCs and cancer cells to maximize the efficacy of breast cancer therapy. HER2 has been found to be overexpressed in both...