BACKGROUND Distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy is clinically characterized by the early involvement of distal leg muscles. The striking pathological features of the myopathy are muscle fibers with rimmed vacuoles. To date, the role of aquaporin-4 water channel in distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy has not been studied. C...

Abstract Sorghum is highly tolerant to alkaline stress, but the underlying mechanisms are not well understood. Here, based on genotypic difference in tolerance of sorghum, it was found that AT1 (Alkaline 1) encoding a G protein involved through negatively modulating phosphorylation level PIP2, an aquaporin with transport activity for H 2 O . Knockout releases its inhibition thereby resulting in...

Cyprinus carpio is a stenohaline species but can tolerate some ranges of changes in environmental salinities, so histomorphological methods and Na+-K+ ATPase and Aquaporin 3 immunohistochemistry were performed on common carp kidney as an osmoregulatory organ in experimental groups and control in order to investigate their possible roles during salinity challenge. Five groups of fish (n=25) with...

To clarify the significance of immunoglobulin G autoantibody specific for the astrocyte water channel aquaporin-4 in cerebrospinal fluid, aquaporin-4-immunoglobulin G from a neuromyelitis optica patient was administered intrathecally to naïve mice, and the distribution and pathogenic impact was evaluated. A distinct distribution pattern of aquaporin-4-immunoglobulin G deposition was observed in...