High-throughput sequencing has enabled genetic screens that can rapidly identify mutations that occur during experimental evolution. The presence of a mutation in an evolved lineage does not, however, constitute proof that the mutation is adaptive, given the well-known and widespread phenomenon of genetic hitchhiking, in which a non-adaptive or even detrimental mutation can co-occur in a genome...

BACKGROUND Identification keys are decision trees which require the observation of one or more morphological characters of an organism at each step of the process. While modern digital keys can overcome several constraints of classical paper-printed keys, their performance is not error-free. Moreover, identification cannot be always achieved when a specimen lacks some morphological features (i....

A headed reinforcing bar is a new type of reinforcement with a T-shaped anchor connected to the end of a reinforcing bar. Conceptually, the bar is usually a tension member or compression one depending on structural engineering applications. The T-shaped anchor, referred to as head in the rest of this report is a relatively stiff steel "plate" in terms of its structural behavior. When embedded i...

BACKGROUND Bar code technology has decreased transcription errors in many healthcare applications. However, we have found that linear bar code identification methods are not failsafe. In this study, we sought to identify the sources of bar code decoding errors that generated incorrect patient identifiers when bar codes were scanned for point-of-care glucose testing and to develop solutions to p...

before constitution revolution, advocacy in our country governed by islamic law and lawyers introduced as a free profession in means of that law. after that revolution the government promulgated some rules for its regulation as an official profession. by act of bar association independence, this profession declared independent. many lawyers after islamic revolution have been filtrated and by th...

BACKGROUND Generation of membrane curvature is critical for the formation of plasma membrane protrusions and invaginations and for shaping intracellular organelles. Among the central regulators of membrane dynamics are the BAR superfamily domains, which deform membranes into tubular structures. In contrast to the relatively well characterized BAR and F-BAR domains that promote the formation of ...

Coordination of membrane deformation and cytoskeletal dynamics lies at the heart of many biological processes critical for cell polarity, motility and morphogenesis. We have recently shown that Slit-Robo GTPase-activating protein 2 (srGAP2) regulates neuronal morphogenesis through the ability of its F-BAR domain to regulate membrane deformation and induce filopodia formation. Here, we demonstra...

the aim of this study was to determine the effect of trenched zirconia bar on the von mises stress distribution of ips -empress ii core ceramics.the three-dimensional model including a three-unit bridge from the second premolar to the second molar was designed. the model was reinforced with zirconia bar (zb), zirconia bar with vertical trench (vzb) and zirconia bar with horizontal trench (hzb) ...