Isoliquiritigenin (ILG) of licorice is a potential cancer chemopreventive agent. In this paper, response surface methodology (RSM) integrating with Box-Behnken design (BBD) was firstly employed to optimize the ILG extraction, which based on the single-factor experiments. According to analysis, the effect of extraction time and ethanol concentration on yields was significantly. The optimum value...

The response surface methodology using the Box-Behnken design was established to describe supercritical carbon dioxide assisted extraction of phyllanthin from Phyllanthus amarus Schum and Thonn leaves prior to HPLC analysis. The effects of extraction pressure, temperature, modifier concentration and extraction time on the yield of phyllanthin were investigated. By solving the regression equatio...

To optimize the production conditions for exopolysaccharides with higher antioxidant activities from Xerocomus badius cultured in shrimp byproduct medium, Plackett-Burman design, path of steepest ascent, and response surface methodology were explored. Based on the results of Plackett-Burman design and path of steepest ascent, a Box-Behnken design was applied to optimization and the regression m...

Insulin therapy has been the best choice for the clinical management of diabetes mellitus. The current insulin therapy is via subcutaneous injection, which often fails to mimic the glucose homeostasis that occurs in normal individuals. Oral delivery is the most convenient administration route. However, insulin cannot be well absorbed orally because of its rapid enzymatic degradation in the gast...

background nowadays, removal of heavy metals from the environment is an important problem due to their toxicity. objectives in this study, a modified method was used to synthesize chitosan-coated magnetite nanoparticles (ccmn) to be used as a low cost and nontoxic adsorbent. ccmn was then employed to remove hg2+ from water solutions. materials and methods to remove the highest percentage of mer...

This paper discusses the use of Box Behnken design (BBD) approach to plan the experiments for turning the yield of CVD, thickness and layer number of graphene sheets with an overall objective of optimizing the process to provide higher graphene production volume, fewer layers and thinness structure of graphene. BBD is having the maximum efficiency for an experiment involving four factors such a...

the main objective of the present study is to investigate the feasibility of using carboxymethyl chitosan magnetic nanoparticles (ccmn) for the adsorption of cd2+. the study also reports important parameters, which affect the adsorption process, i.e., ph, adsorbent dose, contact time and concentration of cd2+, using box-behnken designs. firstly, functional carboxymethyl chitosan magnetic nanopa...

introduction: fructans are an important product of the industry of prebiotics. in addition to their interesting nutritional and health benefit properties, fructans are also used in food formulations for their techno-functional properties such as fat substitute, bulk agent, water retention. serish (eremurus spectabilis) belongs to the family of liliaceae and geographically distributed in the reg...