Cationic dry strength agents (DSAs) are commonly used for paper strengthening. However, before they are applied, another chemical called an anionic trash catcher (ATC) is often used to pretreat pulp to neutralize the negative dissolved and colloidal substances (DCS), increasing the effectiveness of the subsequently added cationic DSA. However, in many cases, the negativity of the fibers is also...

The analytical target cascading (ATC) optimization technique for hierarchical systems demonstrates convergence properties only under assumptions of convexity and continuity. Many practical engineering design problems, however, involve a combination of continuous and discrete variables resulting in the development of mixed integer nonlinear programming (MINLP) formulations. While ATC has been ap...

Anaplastic thyroid carcinoma (ATC) is an uncommun and highly aggressive malignancy. Differentiated follicular and papillary thyroid carcinomas account for most (80-90%) thyroid malignancies with ATC accounting for less than 5%. A diagnosis of ATC is usually fatal with a mean survival of 3-9 months and only 10-15% alive at 2 years. Histologic examination reveals that many of them contain a papil...

|This paper concentrates on studying the e ect of SVC and TCSC controllers on the Available Transfer Capability (ATC). Standard voltage collapse techniques are used to determine the ATC of a test system, considering a variety of system limits. Then, based on second-order sensitivity analysis, optimal locations for these particular FACTS controllers are determined; these techniques are compared ...

A different approach for real-time Command and Control problems is presented, using the Air Traffic Control problem as an example. Current ATC approaches use “dynamic” scheduling algorithms, which by their very nature are unpredictable. The current ATC approach is extremely expensive. The April 19, 1999 issue of USA Today places the cost at $41 billion, and the system is not meeting current spe...

PURPOSE Anaplastic thyroid carcinoma (ATC) is one of the most lethal human cancers with a median survival of 6 months. The inhibition of epidermal growth factor receptor (EGFR) alone, or with VEGF receptor 2 (VEGFR2), represents an attractive approach for treatment of ATC. Several reports have examined agents that target these receptors. However, with the misidentification of as many as 60% of ...

Anaplastic thyroid carcinoma (ATC) is a highly aggressive form of the disease for which new therapeutic options are desperately needed. Previously, we showed that the high-affinity peroxisome proliferator-activated receptor gamma (PPARgamma) agonist, RS5444, inhibits cell proliferation of ATC cells via induction of the cyclin-dependent kinase inhibitor p21(WAF1/CIP1) (p21). We show here that up...

Anaplastic thyroid carcinoma (ATC) is the most lethal form of thyroid neoplasia and represents an end stage of thyroid tumor progression. No effective treatment exists so far. In this study, we analyzed the miRNA expression profiles of 11 ATC by microarrays and their relationship with the mRNA expression profiles of the same 11 ATC samples. ATC show distinct miRNA expression profiles compared t...

BACKGROUND Poorly differentiated thyroid carcinoma (PDTC) and anaplastic (undifferentiated) thyroid carcinoma (ATC) comprise a small subset of thyroid tumors that are associated with a poor prognosis and account for a significant portion of the morbidity and mortality related to thyroid cancer. Since management strategies vary between these two entities, it is important for clinicians to be abl...

The Forkhead transcription factor, FoxO3a, is a known suppressor of primary tumor growth through transcriptional regulation of key genes regulating cell cycle arrest and apoptosis. In many types of cancer, in response to growth factor signaling, FoxO3a is phosphorylated by Akt, resulting in its exclusion from the nucleus. Here we show that FoxO3a remains nuclear in anaplastic thyroid carcinoma ...