In non-invasive thermal diagnostics, accurate correlations between the thermal image on skin surface and interior human pathophysiology are often desired, which require general solutions for the bioheat equation. In this paper, a difference scheme for the Pennes equation with a space-dependent thermal physiological parameters and convective boundary condition on the top surface, was used to app...

PURPOSE To develop and validate a computational model that simulates (1) tissue heating with high intensity focused ultrasound (HIFU), and (2) resulting hyperthermia-mediated drug delivery from temperature-sensitive liposomes (TSL). MATERIALS AND METHODS HIFU heating in tissue was simulated using a heat transfer model based on the bioheat equation, including heat-induced cessation of perfusio...

A three-dimensional mathematical model was developed to examine the induction of selective brain cooling (SBC) in the human brain by intracarotid cold (2.8 degrees C) saline infusion (ICSI) at 30 ml/min. The Pennes bioheat equation was used to propagate brain temperature. The effect of cooled jugular venous return was investigated, along with the effect of the circle of Willis (CoW) on the intr...

In non-invasive thermal diagnostics, accurate correlations between the thermal image on skin surface and interior human pathophysiology are often desired, which require general solutions for the bioheat equation. In this paper, a difference scheme for the Pennes with a space-dependent thermal physiological parameters and convective boundary condition on the top surface, was used to approximate ...

Objective To create an improved planning method for pediatric regional hyperthermia (RHT) using the SIGMA-30 applicator (SIGMA-30).Materials and Methods An electromagnetic model of was generated use with finite-difference time-domain (FDTD) method. Applying special MATLAB-based algorithms, voxel models a patient pelvic rhabdomyosarcoma were created from Computed-Tomography (CT) contours FDTD (F...

Radio-frequency ablation (RFA) is a minimally invasive treatment that can provide highly localized and precise cancer therapy. Despite these advantages, its application in clinical practice remains limited. This primarily due to the insufficient volume, where blood perfusion plays significant role. In this study, computational modeling applied examine effects of heterogeneous on tissue temperat...

In non-invasive thermal diagnostics for the location of a tumor, accurate correlations between the thermal image on skin surface and interior human physiology are often desired, which require general solutions for the bioheat equation. In this paper we use sensitivity analysis in order to compute the shape derivative of the funtional that provides the minimum (the geometrical position of the tu...