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BACKGROUND Abnormalities in white matter (WM) have previously been reported in patients with obsessive-compulsive disorder (OCD). However, there was some inconsistency in the results obtained for altered regions of WM. The aim of this study was to investigate fractional anisotropy (FA) in the WM of the whole brain in patients with OCD by using diffusion tensor imaging (DTI). METHODS In total,...
OBJECTIVES To determine whether juvenile obsessive-compulsive disorder (OCD) is familial and whether the rate of Tourette syndrome (TS) and tic disorders is higher among relatives of patients with OCD than among relatives of controls subjects. METHOD We assessed first-degree relatives of 35 juvenile OCD probands (aged 16 years or less) and 34 matched, psychiatrically unaffected control subjec...
BACKGROUND Deep brain stimulation (DBS) has been proposed as an alternative to ablative neurosurgery for severe treatment-resistant Obsessive-Compulsive Disorder (OCD), although with partially discrepant results probably related to differences in anatomical targetting and stimulation conditions. We sought to determine the efficacy and tolerability of DBS in OCD and the existence of clinical pre...
2. INTERFERENCE DUE TO OBSESSIVE THOUGHTS SCORE __________ How much do your obsessive thoughts interfere with your work, school, social, or other important role functioning? Is there anything that you don’t do because of them? 0 = None 1 = Slight interference with social or other activities, but overall performance not impaired 2 = Definite interference with social or occupational performance, ...
OBJECTIVE This study examined the time course of efficacy-related endpoints for lisdexamfetamine dimesylate (LDX) versus placebo in adults with protocol-defined moderate to severe binge-eating disorder (BED). METHODS In two 12-week, double-blind, placebo-controlled studies, adults meeting DSM-IV-TR BED criteria were randomized 1:1 to receive placebo or dose-optimized LDX (50 or 70 mg). Analys...
Introduction: Despite the common sociocultural background in the Arab world, considerable differences exist between its different countries. Aim of the Study: The study was conducted aiming at evaluating the impact of obsessive compulsive disorder on patients’ life in two relatively different Arab cultures and the implication of these cultures on OCD presentation and symptomatology. Subjects an...
BACKGROUND Severe, refractory obsessive-compulsive disorder (OCD) is a disabling condition. Stimulation of the subthalamic nucleus, a procedure that is already validated for the treatment of movement disorders, has been proposed as a therapeutic option. METHODS In this 10-month, crossover, double-blind, multicenter study assessing the efficacy and safety of stimulation of the subthalamic nucl...
Introduction Obsessive-compulsive disorder (OCD) is connected with increased activity in cortico-striatal-thalamic-cortical (CSTC) loop. The anterior cingulate cortex (ACC) a part of this loop and plays role error detection monitoring processing conflicting information, core OCD clinical signs. This area also contains high density Von Economo neurons. Biochemistry closely the pathophysiology OC...
AbstractIntroduction: The objective of the current investigation was to introduce the metacognitive model of obsession and to Explore the efficacy and effectiveness of this model in the treatment of ob- sessive compulsive disorder.Method: In a single-subject experimental trial of multiple baseline type, the treatment process was carried out on a female subject. The subject was assessed at both...
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