The pathogenesis of viral myocarditis (VMC) is not fully understood. This study aimed to examine the relationship between coxsackie-adenovirus receptor (CAR) and the p38 mitogen activated protein kinase (MAPK) pathway mechanisms in a mouse model. Three groups of mice were established: 5 mice in a control group injected with saline, 15 in the model group injected with coxsackie virus B3 (CVB) an...

Despite the impressive clinical efficacy of T cells engineered to express chimeric antigen receptors (CAR-Ts), the current applications of CAR-T cell therapy are limited by major treatment-related toxicity. Thus, safer yet effective alternative approaches must be developed. In this study, we compared CD19 bispecific T-cell engager (BiTE)-transferred T cells that had been transfected by RNA elec...

Nowadays, using advanced vehicle control and safety systems in vehicles is growing rapidly. In this regard, in recent years new control systems, called VDC, have been introduced. These systems stabilize vehicle yaw motion, by yaw moment resulted from tire controlling forces. In this paper, an adaptive optimal controller applied to a vehicle to obtain a satisfactory lateral and yaw stability. To...

The predictive power of the Ajzen, Triandis, and Schwartz models are compared in the context of car use for university routes. Two hundred fifty-four students filled out a questionnaire designed to measure the components of the three models. In the prediction of intention to use a car, results indicated that one variable from the Trinandis model—role beliefs—increased the explanatory power offe...

In classic passive suspension design, comfort and road handling are conflicting design criteria. An active or semi-active suspension offers the possibility to vary the damper characteristics along with the road profile. Such systems have discrete settings or are limited in bandwidth up to 10Hz. This paper discusses the development of a controller for a passenger car using a recently developed a...

We consider a semi-discrete car-following model and the macroscopic Aw–Rascle model for traffic flow given in Lagrangian form. The solution of the car-following model converges to a weak entropy solution of the system of hyperbolic balance laws with Cauchy initial data. For the homogeneous system, we allow vacuum in the initial data. By using properties of the semi-discrete model, we show that ...

Following immune attack, solid tumors upregulate coinhibitory ligands that bind to inhibitory receptors on T cells. This adaptive resistance compromises the efficacy of chimeric antigen receptor (CAR) T cell therapies, which redirect T cells to solid tumors. Here, we investigated whether programmed death-1-mediated (PD-1-mediated) T cell exhaustion affects mesothelin-targeted CAR T cells and ex...

This paper deals with single-wheel suspension car model. The benefits of controlled semi-active suspensions compared to passive ones are here emphasized. The contribution relies on robust analysis of a controller which improves comfort and road holding of the car under industrial specifications. Simulations on an exact nonlinear model of the suspension are performed for control validation.

Ecological data often exhibit spatial pattern, which can be modeled as autocorrelation. Conditional autoregressive (CAR) and simultaneous autoregressive (SAR) models are network-based models (also known as graphical models) specifically designed to model spatially autocorrelated data based on neighborhood relationships. We identify and discuss six different types of practical ecological inferen...