A modular synthesis of tetrasubstituted furan carboxylates using a tandem cycloisomerization/oxidative carbonylation sequence of cyclopropenes has been successfully developed. The Tandem Metal Relay Catalysis (TMRC) pathway accounted for the high efficiency of this transformation.

An efficient method for the synthesis of N-aryl monosubstituted carboxamides via the Pd-catalyzed carbonylation of alkenes with CO and amines is described. Mechanistic insights for this highly selective reaction are provided.

Oxidative carbonylation of amines using NaIO(4) as the oxidant and NaI as a promoter affords good to excellent yields of ureas from primary amines in the absence of transition metal catalysts.

Use of a bulky bidentate bis(NHC) ligand allows isolation of a stable cationic methylpalladium carbonyl complex that undergoes clean carbonylation to an acyl complex under excess CO, modeling a key step in CO/alkene copolymerization.

Although the genome contains all the information necessary for maintenance and perpetuation of life, it is the proteome that repairs, duplicates and expresses the genome and actually performs most cellular functions. Here we reveal strong phenotypes of physiological oxidative proteome damage at the functional and genomic levels. Genome-wide mutations rates and biosynthetic capacity were monitor...

Several examples on Pd-catalysed carbonylation of methyl C(sp3)-H bonds with gaseous CO via Pd(II)/Pd(0) catalysis have been reported. However, methylene C(sp3)-H carbonylation remains a great challenge, largely due to the lack of reactivity of C-H bonds and the difficulty in CO migratory insertion. Herein, we report the stereoselective alkoxycarbonylation of both methyl and methylene C(sp3)-H ...

Ohr, a bacterial protein encoded by the Organic Hydroperoxide Resistance (ohr) gene, plays a critical role in resistance to organic hydroperoxides. In the present study, we show that the Cys-based thiol-dependent Ohr of Corynebacterium glutamicum decomposes organic hydroperoxides more efficiently than hydrogen peroxide. Replacement of either of the two Cys residues of Ohr by a Ser residue resul...

Caloric restriction (CR) has been associated with health benefits and these effects have been attributed, in part, to modulation of oxidative status by CR; however, data are still controversial. Here, we investigate the effects of seventeen weeks of chronic CR on parameters of oxidative damage/ modification of proteins and on antioxidant enzyme activities in cardiac and kidney tissues. Our resu...