BACKGROUND This study examines whether the association of diabetes with the rate of cognitive decline varies according to dementia severity. METHODS Longitudinal study on subjects residing in nursing homes and assisted living (n = 342). The Mini Mental State Examination (MMSE) was used to measure the rate of cognitive decline in diabetic and nondiabetic subjects who were nondemented (Clinical...

The occurrence of falls in AD patients is frequent, and their consequences are cognitive decline, fractures and loss of independence. Many studies have addressed fall risk factors in order to establish effective prevention strategies. Objectives We describe the frequency and characteristics of falls in a sample of AD patients and their main risk factors. Methods We evaluated 40 subjects wit...

Since 1998, the Food and Agriculture Organization of the United Nations (FAO) has been publishing its electronic publications in the FAO Corporate Document Repository (CDR). The electronic publishing workflow is maintained by the Electronic Information Management System (EIMS). The EIMS-CDR holds more than 38 500 documents and is the gateway to FAO's publications. The EIMS-CDR coexists with the...

The antigen-binding site of antibodies, also known as complementarity-determining region (CDR), has hypervariable sequence properties. In particular, the third CDR loop of the heavy chain, CDR-H3, has such variability in its sequence, length, and conformation that ordinary modeling techniques cannot build a high-quality structure. At Stage 2 of the Second Antibody Modeling Assessment (AMA-II) h...

The aim of this study was to develop a brief informant-based questionnaire, namely the Symptoms of Early Dementia-11 Questionnaire (SED-11Q), for the screening of early dementia. 459 elderly individuals participated, including 39 with mild cognitive impairment in the Clinical Dementia Rating scale (CDR) 0.5, 233 with mild dementia in CDR 1, 106 with moderate dementia in CDR 2, and 81 normal con...

Autoradiographic studies of lymphoid tissue with tritiated thymidine ([3H]TdR) have repeatedly demonstrated that thymus lymphocytes and germinal-center cells of lymph nodes and spleen are characterized by a weak labeling, whereas the majority of lymph node lymphocytes which occur outside of the germinal centers are intensely labeled (1-7) . An earlier study on mice by Osogoe and Ueki (8), on th...

The pervasiveness and availability of mobile phone data offer the opportunity of discovering usable knowledge about crowd behavior in urban environments. Cities can leverage such knowledge to provide better services (e.g., public transport planning, optimized resource allocation) and safer environment. Call Detail Record (CDR) data represents a practical data source to detect and monitor unusua...

PURPOSE To compare moderate and advanced glaucoma patients in Ghana. METHODS A retrospective cross-sectional study of 164 patients with primary open-angle glaucoma (POAG) were separated into moderate and advanced glaucoma groups. Definitions of moderate and advanced POAG were derived from International Geographical and Epidemiologic Ophthalmology criteria and included clinical assessment of o...

Many murine monoclonal anti-DNA antibodies (Abs) derived from mice models for systemic lupus erythematosus have additional cell-penetration and/or nucleic acid-hydrolysis properties. Here, we examined the influence of deactivating each complementarity-determining region (CDR) within a multifunctional anti-nucleic acid antibody (Ab) that possesses these activities, the catalytic 3D8 single chain...

In hepatocellular cancer (HCC), lack of response to chemotherapy and radiation treatment can be caused by a loss of epigenetic modifications of cancer cells. Methionine adenosyltransferase 1A is inactivated in HCC and may be stimulated by an epigenetic change involving promoter hypermethylation. Therefore, drugs releasing epigenetic repression have been proposed to reverse this process. We stud...