In a case of acute promyelocytic leukemia (APL), the expression of terminal deoxynucleotidyl transferase (TdT), an early lymphoid marker, was detected. Double-fluorescent staining for the myeloid-specific antigens VIM-2 and VIM-D5 in combination with specific antiserum for TdT suggested a mixed leukemic cell population consisting of a morphologically, cytochemically, and immunologically promyel...

Dendritic cells (DCs) are important for the initiation of immune responses to foreign antigens. Their antigen uptake and presentation capacities enable them to prime and activate T cells. Immature DCs capture antigens; however, they must be activated to mature before serving as efficient antigen-presenting cells. The antigen-presenting capacity of DCs can be diminished during viral infection an...

a random 12 mers phage library was used to screen a pool of immunoglo¬bulin fractions obtained from vitiligo patients. subsequent to panning experiments, a panel of affinity selected phage from vitiligo patients were obtained. this panel was tested using an elis a for their reactivity with pooled sera from patients and normal controls. among the 16 randomly selected clones, two of clones showed...

mesenchymal stem cells can be obtained from deferent tissues like adipose tissue, umbilical cord, placenta, skin, bone marrow, etc. these cells have regulatory effects on all types of immune cells such as dendritic cell, natural killers and lymphocytes. mesenchymal stem cells induce inhibitory phenotypes of antigen presenting cells (apcs) following their activity. they also change t cells pheno...

conclusions w. coagulans inhibits the development of bph can be useful for the treatment of this condition. results the present study revealed that bph caused elevation of mda levels, suppression of tac levels, and increased pcna expression in the prostate gland. interestingly, in a dose-dependent manner, wce caused decreased mda levels and increased tac levels in the prostate gland, compared t...

in teleosts the insulin-like growth factor-i, a member of igf system, play an important role in the control of growth and reproduction including metabolism, cell division, oogenesis, final oocyte maturation and secretory activity. this system is controlled by several hormones and metabolic status. serum igf-i, thyroxine (t4) and cortisol levels were studied in two female brood stocks (caught fr...

Despite the discoveries of numerous agents including next generation proteasome inhibitors, immunomodulatory drugs, and monoclonal antibodies, multiple myeloma (MM) remains an incurable disease. The field treatment in refractory or relapsed patients after standard therapy entered a new era due to B-cell maturation antigen (BMCA) targeted approach. BCMA is member tumor necrosis factor receptor f...

Insulin-like growth factors (IGFs) can promote tumorigenesis via inhibiting the apoptosis of cancer cells. The relationship between IGFs and dendritic cell (DC)-mediated immunity were investigated. Advanced-stage ovarian carcinoma patients were first evaluated to show higher IGF-1 and IGF-2 concentrations in their ascites than early-stage patients. IGFs could suppress DCs' maturation, antigen p...