نتایج جستجو برای: cell maturation antigen
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مقدمه: نقص ایمنی متغیر شایع (common variable immunodeficiency یا cvid)، فراوان ترین نارسایی ایمنی اولیه از نظر بروز علایم بالینی و مجموعه شرایط ناهمگنی است که با کمبود ارثی آنتی بادی (هایپوگاماگلوبولینمی) از حداقل دو ایزوتیپ ایمونوگلوبولین به همراه اختلال در بلوغ سلول های b و جهش سوماتیک، کاهش تعداد سلول های خاطره ی تعویض کلاس شده و نشده در گردش خون و اغلب با نبود پلاسماسل شناخته می شود. b-cell...
Idecabtagene vicleucel (ide-cel, also called bb2121), a B-cell maturation antigen–directed chimeric antigen receptor (CAR) T-cell therapy, has shown clinical activity with expected CAR toxic effects in patients relapsed and refractory multiple myeloma.
The maturation of B cells leads to the synthesis highly evolved immunoglobulins (Igs) that enable efficient antigen-antibody recognition. Here we discuss a non-opportunistic, combinatorial concept “maturation” Igs in silico for production artificially-evolved immunocatalysts. Several recent breakthroughs including: (i) single cell selection using microfluidic technology (ii) approaches powered ...
Background and purpose: As professional antigen- presenting cells, dendritic cells are a bridge between innate and adaptive immunity by stimulating T lymphocytes. Recent research has demonstrated the extra ability of the myeloid cells plasticity into different cells in response to environmental stimuli. In the present study, the effect of using combination maturation factors (MCM, TNF-α, poly (...
Serum B-cell maturation antigen: a novel biomarker to predict outcomes for multiple myeloma patients
B-cell maturation antigen is expressed on plasma cells. In this study, we have identified serum B-cell maturation antigen as a novel biomarker that can monitor and predict outcomes for multiple myeloma patients. Compared to healthy donors, patients with multiple myeloma showed elevated serum B-cell maturation antigen levels (P<0.0001). Serum B-cell maturation antigen levels correlated with the ...
background: dendritic cells (dcs) are professional antigen presenting cells that have an important role in the initiation of immune response. the use of maturation factors in dendritic cell differentiation provides a promising approach in immunotherapy. objective: in this study, we compared tumor necrosis factor-α, polyribocytidylic acid, lipopolysacharide and cpg oligonucleotides in inducing d...
During an immune response antigen-primed B-cells increase their antigen responsiveness by affinity maturation mediated by somatic hypermutation of the genes encoding the antigen-specific B-cell receptor (BCR) and by selection of higher-affinity B cell clones. Unlike the BCR, the T-cell receptor (TCR) cannot undergo affinity maturation. Nevertheless, antigen-primed T cells significantly increase...
Background: Dendritic cells (DCs) are professional antigen presenting cells that have an important role in the initiation of immune response. The use of maturation factors in dendritic cell differentiation provides a promising approach in immunotherapy. Objective: In this study, we compared tumor necrosis factor-α, polyribocytidylic acid, lipopolysacharide and CpG oligonucleotides in inducing d...
Background & Aims: Dendritic cells are the most potent antigen presenting cells in induction or polarization of T-dependent immune responses. In cancerous patients, suppressive or detoured immune responses regard to tumor cells, prevent appropriate functions of dendritic cells. Nowadays, in vitro production, expansion and maturation of dendritic cells in presence of safe maturation factors whi...
Back ground: Candida albicans is a member of the normal human microflora. C. albicans cell wall is composed of several protein and carbohydrate components which have been shown to play a crucial role in C. albicans interaction with the host immune system. Major components of C. albican cell wall are carbohydrates such as mannans, β glucans and chitins, and proteins that partially modulate the h...
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