نتایج جستجو برای: chromosome 10q
تعداد نتایج: 119424 فیلتر نتایج به سال:
The author uses an elementary lemma on primes dividing binomial coefficients and estimates for primes in arithmetic progressions to sharpen a theorem of J. Rickert on simultaneous approximation to pairs of algebraic numbers. In particular, it is proven that max {∣∣∣∣√2− p1 q ∣∣∣∣ , ∣∣∣∣√3− p2 q ∣∣∣∣} > 10−10q−1.8161 for p1, p2 and q integral. Applications of these estimates are briefly discussed.
Previous cytogenetic studies of primary cutaneous T-cell lymphoma (CTCL) were based on limited numbers of patients and seldom showed consistent nonrandom chromosomal abnormalities. In this study, 54 tumor DNA samples from patients with CTCL were analyzed for loss of heterozygosity on 10q. Allelic loss was identified in 10 samples, all of which were from the 44 patients with mycosis fungoides (1...
Prostate cancer incidence is steadily increasing in Western industrialized countries where it has become the most common male malignancy and second most common cause of cancer death among men. Despite efforts to understand the mechanisms of prostate cancer development and progression, the reasons for the disease remain unclear. Although recurrent DNA copy number aberrations in prostate cancer h...
Detailed genetic profiling of clear cell renal cell carcinoma (ccRCC) has revealed genomic regions commonly affected by structural changes and a general genetic heterogeneity. VHL and PBRM1, both located at chromosome 3p, are 2 major genes mutated at high frequency but apart from these aberrations, the mutational landscape in ccRCC is largely undefined. Potential prognostic information given by...
cml in breif cml is characterized by the proliferation of large numbers of immature wbc in the blood and bone marrow. in most of the patients , it is a clonal disorder in which all cell lines, express the philadelphia chromosome)q/22 translocation(it accounts for 20 of all leukemias and most cases occur over 25 yrs of age. the disease usually begins insidiously,but symptoms referable to anemia ...
Abstract Background The evolutionary processes that drive tumor progression in patients with IDH-mutant astrocytoma remain largely unclear. GLASS-NL consortium was initiated to gain insight into the molecular mechanisms underlying glioma evolution and identify markers of astrocytomas. Ultimately, such can assist clinical decision making. Here, we present DNA methylation profiling, RNA-sequencin...
There is a lack of consistently linked loci influencing blood pressure and hypertension status, and this may be because of genetic or phenotypic heterogeneity. We hypothesize that stratification of subjects by response to antihypertensive drug groups could be used to stringently define subsets that will have reduced genetic and etiologic heterogeneity, by partitioning contrasting mechanisms of ...
Medulloblastoma encompasses a group of aggressively growing cancers that arise either in the cerebellum or brain stem. They present primarily in children, with 80-85 % of medulloblastomas being diagnosed in patients of 16 years and younger. In adults, medulloblastomas are rare and account for less than 1 % of intracranial malignancies. Due to the low incidence of medulloblastoma in adults, the ...
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