The stability of colloidal dispersions is of crucial importance because the properties of dispersions are strongly affected by the degree of coagulation. Whereas the coagulation kinetics for quiescent (i.e., nonstirred) and diluted systems is well-established, the behavior of concentrated dispersions subjected to shear is still not fully understood. We employ the discrete element method (DEM) f...

Bachmann and coworkers in Chicago have performed a careful study of coagulation parameters after cardiopulmonary bypass surgery .1 In 512 patients, they found a 4% incidence of postoperative bleeding. More than half of these cases were due to surgically correctable causes. About 2% of the population were considered to be bleeding because of an acquired coagulation disorder. One half of these ca...

OBJECTIVE Blood flow is considered one of the important parameters that contribute to venous thrombosis. We quantitatively test the relationship between initiation of coagulation and shear rate and suggest a biophysical mechanism to understand this relationship. METHODS AND RESULTS Flowing human blood and plasma were exposed to cylindrical surfaces patterned with patches of tissue factor (TF)...

In light coagulation, thermal Parameters play an important role for the biological reaction. Therefore, we measured the temperature increase and the whitening of the coagulation site simultaneously during the coagulation. Microthermocouples [I] were developed as shown in figure 1. The diameter of the tip ranges between 5 and 10 pm, the response time of this element is in the region of 1 msec. W...

BACKGROUND Pathogenesis of intraventricular hemorrhage (IVH) in premature infants is multifactorial. Little is known about the impact of genetic variants in the vitamin K-dependent coagulation system on the development of IVH. METHODS Polymorphisms in the genes encoding vitamin K epoxide reductase complex 1 (VKORC1 -1639G>A) and coagulation factor 7 (F7 -323Ins10) were examined prospectively ...

BACKGROUND Blue Rubber Bleb Nevus Syndrome (BRBNS) is a rare condition which usually manifests as multiple hemangioma-like skin and gastrointestinal lesions. The latter often present with chronic bleeding. There is no consensus regarding the optimal management of such patients. Although rare, complications such as intestinal intussusception might occur, demanding surgical treatment. Postoperati...

Thrombotic events are among the most dangerous complications of pregnancy. Therefore, selection appropriate tests and standardization techniques used for accurate diagnostics blood coagulation system state is great importance. In this present study, we monitored several molecular markers dangers intravascular thrombus formation estimated platelet function in pregnant women during­ gestation. We...