We examined whether modulation of functional connectivity by cognitive state differed between pre-adolescent children with Autism Spectrum Disorders (ASD) and age and IQ-matched control children. Children underwent functional magnetic resonance imaging (fMRI) during two states, a resting state followed by a sustained attention task. A voxel-wise method was used to characterize functional connec...

OBJECTIVE Temporal lobe epilepsy (TLE) affects brain areas beyond the temporal lobes due to connections of the hippocampi and other temporal lobe structures. Using functional connectivity magnetic resonance imaging (MRI), we determined the changes of hippocampal networks in TLE to assess for a more complete distribution of abnormality. METHODS Regions of interest (ROIs) were defined in the ri...

Homologous neural networks seem to exist in the human left and right hemispheres tightly linking cortical regions straddling the sylvian fissure. White matter fiber bundles connect the inferior parietal lobule with the ventrolateral frontal cortex, ventrolateral frontal cortex with superior/middle temporal cortex, and superior/middle temporal cortex with the inferior parietal lobule. It is argu...

I applaud the authors of the article “Can temporal repetitive transcranial magnetic stimulation be enhanced by targeting affective components of tinnitus with frontal rTMS? a randomized controlled pilot trial” because many of them are pioneers in the development of protocols that use rTMS to treat chronic tinnitus. Investigators (including myself) around the world conducting similar studies of ...

Previous studies suggest that nocebo effects, sometimes termed "negative placebo effects," can contribute appreciably to a variety of medical symptoms and adverse events in clinical trials and medical care. In this study, using a within-subject design, we combined functional magnetic resonance imaging (fMRI) and an expectation/conditioning manipulation model to investigate the neural substrates...

ackground: The purpose of this study was to assess interregional brain activity covariations during traumatic script-driven imagery n subjects with posttraumatic stress disorder (PTSD). ethods: Functional magnetic resonance imaging and functional connectivity analyses were used to assess interregional brain ctivity covariations during script-driven imagery in PTSD subjects with a dissociative r...

Early-life stress (ELS) exposure is associated with adverse outcomes across the lifespan. We examined the relation of ELS exposure to resting-state fMRI in children ages 4-7 years. ELS in the first years of life, but not concurrent, was associated with higher regional homogeneity of resting-state fMRI in the left lateral frontal cortex. Resting-state fMRI functional connectivity analyses showed...