purpose: the antigen binding fragments of camelids heavy chain antibodies are comprised in one single domain (vhh). the crystal structure of an isolated vhh indicated that it is a problate particle of 2.5 nm in diameter and ∼4 nm high, and has been referred to as a nanobody. the very close similarity of these molecules to human vhs illustrates the potential application of these novel products ...

In the present study, the conjugate turbulent free convection with the thermal surface radiation in a rectangular enclosure bounded by walls with different thermophysical characteristics in the presence of a local heater is numerically studied. The effects of surface emissivity and wall materials on the air flow and the heat transfer characteristics are the main focus of the present investigati...

Gluten hydrolysate was prepared through limited enzymatic hydrolysis of wheat gluten resulting from the byproducts of wheat starch. The enzyme applied in the present study was Protamex. Response surface methodology was used to investigate the effects of pH, gluten hydrolysate (GHP)/ -carrageenan ( C) ratio and reaction time on emulsifying properties of the GHPC conjugate. The regression model f...

Saccades made between targets at optical infinity require both eyes to rotate by the same angle. Nevertheless, these saccades are consistently accompanied by transient vergence eye movements. Here we have investigated whether the dynamics of these vergence movements depend on the trajectory of the coincident conjugate movement, and whether moving the head during eye-head gaze shifts modifies ve...

Abstract The method of characteristics is extended to set-valued Hamilton-Jacobi equations. This problem arises from a calculus variations’ with multicriteria Lagrangian function: through an embedding into framework, equation derived, where the Hamiltonian function Fenchel conjugate function. In this paper described and some results are given for conjugate.

Methotrexate (MTX) was conjugated to an immunoglobulin G1 (IgG1) monoclonal antibody specific for human prostatic acid phosphatase (PAP) by the active ester method. The molar ratio of MTX to IgG was 14. MTX-monoclonal antibody conjugate retained substantially the original PAP-binding inhibition activity of the monoclonal antibody. Both MTX-monoclonal antibody conjugate and an identically prepar...

This report reviews conjugate priors and priors closed under sampling for a variety of data generating processes where the prior distributions are univariate, bivariate, and multivariate. The effects of transformations on conjugate prior relationships are considered and cases where conjugate prior relationships can be applied under transformations are identified. Univariate and bivariate prior ...

Currently, there is no therapy for men with androgen-refractory prostate cancer that substantially extends survival. This report characterizes by in vitro and in vivo techniques a new chemotherapeutic that is composed of desacetyl-vinblastine covalently linked to a peptide that contains a peptide bond that can be hydrolyzed by prostate-specific antigen (PSA). This compound (referred to as vinbl...

A bovine serum albumin-conjugated doxorubicin via the glutaraldehyde bridge (BSA-DXR conjugate) showed potent dose-dependent inhibition of cell growth against daunorubicin-resistant AH66 (AH66DR) cells as well as parental AH66 (AH66P) cells in vitro as compared to treatment with DXR or BSA-glutaraldehyde conjugate without DXR (BSA-GA). In the culture of AH66DR with BSA-DXR conjugate, drug accum...

AIM This work is intended to develop and evaluate a biopolymeric poly(L-γ-glutamylglutamine) (PGG)-docetaxel (DTX) conjugate that can spontaneously self-assemble in aqueous solutions to become nanoparticles. METHODS DTX was covalently attached to hydrophilic PGG by direct esterification, and the conjugate was characterized by proton nuclear magnetic resonance spectroscopy, molecular weight ge...